The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

sbmC  -  DNA gyrase inhibitor

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK2003, JW1991, dgi, gyrI, yeeB
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of sbmC


High impact information on sbmC


Chemical compound and disease context of sbmC


Biological context of sbmC

  • sbmC, a stationary-phase induced SOS Escherichia coli gene, whose product protects cells from the DNA replication inhibitor microcin B17 [11].
  • The region seems to contain four core binding sites (designated sbmA, sbmB, sbmC, and sbmD), each consisting of a similar number of nucleotides and including a homologous 15-bp sequence [12].
  • In the present work, we have investigated the regulation of sbmC expression during SOS induction and the stationary growth phase using a single-copy sbmC'-'lacZ fusion [13].
  • These findings demonstrate that H-NS regulates the sbmC expression via H-NS's direct binding to the promoter region [13].
  • The gyrI (also called sbmC) gene product inhibits DNA gyrase activity in vitro, while the rob protein appears to function in transcriptional activation of efflux pumps [14].

Associations of sbmC with chemical compounds


Other interactions of sbmC

  • The gene is located at min 44 of the E. coli genetic map, close to the sbcB gene. sbmC expression is induced by DNA-damaging agents and, also, by the entry of cells into the stationary growth phase [11].
  • Mutation in rpoS or hns causes the repression of the sbmC gene during the stationary growth phase [13].
  • A mukB null mutant is hypersensitive to the DNA gyrase inhibitor novobiocin [20].

Analytical, diagnostic and therapeutic context of sbmC


  1. Identification of DNA gyrase inhibitor (GyrI) in Escherichia coli. Nakanishi, A., Oshida, T., Matsushita, T., Imajoh-Ohmi, S., Ohnuki, T. J. Biol. Chem. (1998) [Pubmed]
  2. Cyclothialidine and its congeners: a new class of DNA gyrase inhibitors. Goetschi, E., Angehrn, P., Gmuender, H., Hebeisen, P., Link, H., Masciadri, R., Nielsen, J. Pharmacol. Ther. (1993) [Pubmed]
  3. Bacteriophage lambda promoters pL and pR: sequence determinants of in vivo activity and of sensitivity to the DNA gyrase inhibitor, coumermycin. Kincade, J.M., deHaseth, P.L. Gene (1991) [Pubmed]
  4. The effect of novobiocin on solvent production by Clostridium acetobutylicum. Wong, J., Bennett, G.N. J. Ind. Microbiol. (1996) [Pubmed]
  5. Stimulation of a Chlamydomonas chloroplast promoter by novobiocin in situ and in E. coli implies regulation by torsional stress in the chloroplast DNA. Thompson, R.J., Mosig, G. Cell (1987) [Pubmed]
  6. Torsional tension in the DNA double helix measured with trimethylpsoralen in living E. coli cells: analogous measurements in insect and human cells. Sinden, R.R., Carlson, J.O., Pettijohn, D.E. Cell (1980) [Pubmed]
  7. Posttranslational modifications in microcin B17 define an additional class of DNA gyrase inhibitor. Yorgey, P., Lee, J., Kördel, J., Vivas, E., Warner, P., Jebaratnam, D., Kolter, R. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  8. Characterization of the interaction between DNA gyrase inhibitor and DNA gyrase of Escherichia coli. Nakanishi, A., Imajoh-Ohmi, S., Hanaoka, F. J. Biol. Chem. (2002) [Pubmed]
  9. Glutamate racemase is an endogenous DNA gyrase inhibitor. Ashiuchi, M., Kuwana, E., Yamamoto, T., Komatsu, K., Soda, K., Misono, H. J. Biol. Chem. (2002) [Pubmed]
  10. Escherichia coli cells resistant to the DNA gyrase inhibitor, ciprofloxacin, overproduce a 60 kD protein homologous to GroEL. Hallett, P., Mehlert, A., Maxwell, A. Mol. Microbiol. (1990) [Pubmed]
  11. sbmC, a stationary-phase induced SOS Escherichia coli gene, whose product protects cells from the DNA replication inhibitor microcin B17. Baquero, M.R., Bouzon, M., Varea, J., Moreno, F. Mol. Microbiol. (1995) [Pubmed]
  12. Specific DNA binding of the TraM protein to the oriT region of plasmid R100. Abo, T., Inamoto, S., Ohtsubo, E. J. Bacteriol. (1991) [Pubmed]
  13. The Escherichia coli SOS gene sbmC is regulated by H-NS and RpoS during the SOS induction and stationary growth phase. Oh, T.J., Jung, I.L., Kim, I.G. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  14. In vivo titration of mitomycin C action by four Escherichia coli genomic regions on multicopy plasmids. Wei, Y., Vollmer, A.C., LaRossa, R.A. J. Bacteriol. (2001) [Pubmed]
  15. Complex regulation of the synthesis of the compatible solute ectoine in the halophilic bacterium Chromohalobacter salexigens DSM 3043T. Calderón, M.I., Vargas, C., Rojo, F., Iglesias-Guerra, F., Csonka, L.N., Ventosa, A., Nieto, J.J. Microbiology (Reading, Engl.) (2004) [Pubmed]
  16. Identification of a potent decatenating enzyme from Escherichia coli. DiGate, R.J., Marians, K.J. J. Biol. Chem. (1988) [Pubmed]
  17. Phage P4 DNA replication in vitro. Díaz Orejas, R., Ziegelin, G., Lurz, R., Lanka, E. Nucleic Acids Res. (1994) [Pubmed]
  18. Mechanism of inhibition of DNA gyrase by cyclothialidine, a novel DNA gyrase inhibitor. Nakada, N., Gmünder, H., Hirata, T., Arisawa, M. Antimicrob. Agents Chemother. (1994) [Pubmed]
  19. Synthesis and bacterial DNA gyrase inhibitory properties of a spirocyclopropylquinolone derivative. Wentland, M.P., Perni, R.B., Dorff, P.H., Rake, J.B. J. Med. Chem. (1988) [Pubmed]
  20. Mutants suppressing novobiocin hypersensitivity of a mukB null mutation. Adachi, S., Hiraga, S. J. Bacteriol. (2003) [Pubmed]
WikiGenes - Universities