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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Mutants of translational components that alter reading frame by two steps forward or one step back.

External suppressors, sufS, of a -1 frameshift mutant cause ribosomes to shift into the -1 frame when reading the sequence CAG GGA GUG. The resulting product is not Gln-Gly-Val but Gln-Gly-Ser with Ser being encoded by the underlined AGU. The alleles investigated are approximately 2% efficient in causing frameshifting. Two other suppressors, hopR and hopE of the same -1 frameshift mutant, cause some ribosomes reading the sequence GUG UG to decode a single amino acid, Val, from the five nucleotides. The possibility is considered that peptidyl-tRNA(Val) dissociates from the mRNA, but re-pairs in a triplet manner after the mRNA slips forward by two bases.[1]

References

  1. Mutants of translational components that alter reading frame by two steps forward or one step back. Falahee, M.B., Weiss, R.B., O'Connor, M., Doonan, S., Gesteland, R.F., Atkins, J.F. J. Biol. Chem. (1988) [Pubmed]
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