The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Independent effects of growth hormone releasing factor on growth hormone release and gene transcription.

The synthesis and secretion of growth hormone (GH) by the somatotropic cells of the anterior pituitary is under complex hormonal regulation. The hypothalamic peptides, growth hormone releasing factor (GHRF) and somatostatin, respectively stimulate and block GH release. We have shown that treatment of primary cultures of rat anterior pituitary cells with GHRF stimulates transcription of the GH gene, as well as GH release, and that this reflects the response of pituitary cells in vivo. Gick et al. have shown a stimulation of GH mRNA levels in normal pituitary cells in response to GHRF. Because normal pituitary cells are the physiological target for GHRF and because they exhibit both transcriptional and release responses to the hormone, they provide a valuable system with which to examine the important possibility of a link between hormone synthesis and release in secretory cells. Using this system, we demonstrate here that GHRF stimulates GH gene transcription independently of GH release and, conversely, that other agents can stimulate GH release without affecting transcription of the GH gene.[1]

References

  1. Independent effects of growth hormone releasing factor on growth hormone release and gene transcription. Barinaga, M., Bilezikjian, L.M., Vale, W.W., Rosenfeld, M.G., Evans, R.M. Nature (1985) [Pubmed]
 
WikiGenes - Universities