Use of ethopropazine and BW 284C51 as selective inhibitors for cholinesterases from various species.
Both inhibitors tested were still able to depress the cholinesterase ( ChE) for which it is not selective (BW 284C51 for pseudo ChE, ethopropazine for the true ChE) provided the concentration was high (greater than 10(-2) M). BW 284C51 totally depressed the true ChE activity from bovine erythrocytes at a concentration of 10(-6) M. This inhibitor concentration gave no depression of pseudo ChE activity from horse serum. Ethopropazine totally depressed the pseudo ChE activity from horse serum at a concentration of 5 X 10(-5) M. The true ChE was not inhibited at this concentration. For true ChE from bovine erythrocytes and pseudo ChE from horse serum BW 284C51 and ethopropazine therefore certainly have a potential as selective ChE inhibitors. Ethopropazine at a concentration of 5 X 10(-6) M completely inhibited the pseudo ChE activity in rat plasma and cortex without affecting true ChE activity. BW 284C51 at a concentration of 10(-6) M gave a total depression of the true ChE activity in these preparations. In rat plasma, however, a considerable part of the pseudo ChE activity was depressed at this concentration.[1]References
- Use of ethopropazine and BW 284C51 as selective inhibitors for cholinesterases from various species. Mikalsen, A., Andersen, R.A., Alexander, J. Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. (1986) [Pubmed]
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