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Phenytoin infusion in severe pre-eclampsia.

Intravenous phenytoin sodium was given as a high-dose infusion (10 X 8-18 mg/kg) for anticonvulsive prophylaxis to 2 eclamptic patients and to 24 patients with moderate to severe pre-eclampsia. There were no major maternal or neonatal side-effects. Plasma phenytoin levels were within the therapeutic range (7-20 mg/l) at 30 min and 6 h after the infusion in all patients, and remained at a therapeutic level in 21 patients after 12 h. After a second dose of phenytoin in 19 patients, drug levels were within the therapeutic range at 24 h.[1]

References

  1. Phenytoin infusion in severe pre-eclampsia. Slater, R.M., Wilcox, F.L., Smith, W.D., Donnai, P., Patrick, J., Richardson, T., Mawer, G.E., D'Souza, S.W., Anderton, J.M. Lancet (1987) [Pubmed]
 
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