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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Pre-Eclampsia


Psychiatry related information on Pre-Eclampsia


High impact information on Pre-Eclampsia


Chemical compound and disease context of Pre-Eclampsia

  • Future interventions should make correcting prostacyclin deficiency a major part of the strategy to balance the abnormal vasoconstrictor-vasodilator ratio present in preeclampsia [11].
  • Prostacyclin and thromboxane and the development of preeclampsia [12].
  • CONCLUSIONS: Our results indicate that endothelial function is impaired in women with previous preeclampsia and is not explained by established maternal risk factors but is reversed by antioxidant ascorbic acid administration [13].
  • Because most trials using aspirin to reduce TxA2 production have failed to prevent preeclampsia, it is critical to determine whether eicosanoid changes occur before the onset of clinical disease or are secondary to clinical manifestations of preeclampsia [11].
  • BACKGROUND: Women who took the synthetic estrogen diethylstilbestrol during pregnancy exhibit an elevated risk of breast cancer, whereas those who suffered from preeclampsia, which is associated with low circulating pregnancy estrogens, exhibit a reduced risk [14].
  • Cord serum theobromine concentrations were negatively associated with preeclampsia (aOR = 0.31; CI = 0.11-0.87 for highest compared with lowest quartile) [15].

Biological context of Pre-Eclampsia


Anatomical context of Pre-Eclampsia


Gene context of Pre-Eclampsia


Analytical, diagnostic and therapeutic context of Pre-Eclampsia


  1. Prevention of preeclampsia with low-dose aspirin in healthy, nulliparous pregnant women. The National Institute of Child Health and Human Development Network of Maternal-Fetal Medicine Units. Sibai, B.M., Caritis, S.N., Thom, E., Klebanoff, M., McNellis, D., Rocco, L., Paul, R.H., Romero, R., Witter, F., Rosen, M. N. Engl. J. Med. (1993) [Pubmed]
  2. Risk factors for preeclampsia, abruptio placentae, and adverse neonatal outcomes among women with chronic hypertension. National Institute of Child Health and Human Development Network of Maternal-Fetal Medicine Units. Sibai, B.M., Lindheimer, M., Hauth, J., Caritis, S., VanDorsten, P., Klebanoff, M., MacPherson, C., Landon, M., Miodovnik, M., Paul, R., Meis, P., Dombrowski, M. N. Engl. J. Med. (1998) [Pubmed]
  3. Pulmonary edema after ritodrine therapy in a patient with preeclampsia. Gleicher, N., Bazile, F., Elrad, H. N. Engl. J. Med. (1982) [Pubmed]
  4. Increased AT(1) receptor heterodimers in preeclampsia mediate enhanced angiotensin II responsiveness. AbdAlla, S., Lother, H., el Massiery, A., Quitterer, U. Nat. Med. (2001) [Pubmed]
  5. A meta-analysis of low-dose aspirin for the prevention of pregnancy-induced hypertensive disease. Imperiale, T.F., Petrulis, A.S. JAMA (1991) [Pubmed]
  6. Low-dose aspirin to prevent preeclampsia in women at high risk. National Institute of Child Health and Human Development Network of Maternal-Fetal Medicine Units. Caritis, S., Sibai, B., Hauth, J., Lindheimer, M.D., Klebanoff, M., Thom, E., VanDorsten, P., Landon, M., Paul, R., Miodovnik, M., Meis, P., Thurnau, G. N. Engl. J. Med. (1998) [Pubmed]
  7. Two exonic single nucleotide polymorphisms in the microsomal epoxide hydrolase gene are jointly associated with preeclampsia. Laasanen, J., Romppanen, E.L., Hiltunen, M., Helisalmi, S., Mannermaa, A., Punnonen, K., Heinonen, S. Eur. J. Hum. Genet. (2002) [Pubmed]
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  10. Hypocalciuria in preeclampsia. Taufield, P.A., Ales, K.L., Resnick, L.M., Druzin, M.L., Gertner, J.M., Laragh, J.H. N. Engl. J. Med. (1987) [Pubmed]
  11. Prostacyclin and thromboxane changes predating clinical onset of preeclampsia: a multicenter prospective study. Mills, J.L., DerSimonian, R., Raymond, E., Morrow, J.D., Roberts, L.J., Clemens, J.D., Hauth, J.C., Catalano, P., Sibai, B., Curet, L.B., Levine, R.J. JAMA (1999) [Pubmed]
  12. Prostacyclin and thromboxane and the development of preeclampsia. Benigni, A., Remuzzi, G. JAMA (2000) [Pubmed]
  13. Association of maternal endothelial dysfunction with preeclampsia. Chambers, J.C., Fusi, L., Malik, I.S., Haskard, D.O., De Swiet, M., Kooner, J.S. JAMA (2001) [Pubmed]
  14. Breast cancer risk in rats fed a diet high in n-6 polyunsaturated fatty acids during pregnancy. Hilakivi-Clarke, L., Onojafe, I., Raygada, M., Cho, E., Clarke, R., Lippman, M.E. J. Natl. Cancer Inst. (1996) [Pubmed]
  15. Chocolate consumption in pregnancy and reduced likelihood of preeclampsia. Triche, E.W., Grosso, L.M., Belanger, K., Darefsky, A.S., Benowitz, N.L., Bracken, M.B. Epidemiology (2008) [Pubmed]
  16. Effect of calcium supplementation on pregnancy-induced hypertension and preeclampsia: a meta-analysis of randomized controlled trials. Bucher, H.C., Guyatt, G.H., Cook, R.J., Hatala, R., Cook, D.J., Lang, J.D., Hunt, D. JAMA (1996) [Pubmed]
  17. Decrease prostacyclin production: a characteristic of chronic placental insufficiency syndromes. Stuart, M.J., Clark, D.A., Sunderji, S.G., Allen, J.B., Yambo, T., Elrad, H., Slott, J.H. Lancet (1981) [Pubmed]
  18. Association between susceptibility to pre-eclampsia within families and HLA DR4. Kilpatrick, D.C., Liston, W.A., Gibson, F., Livingstone, J. Lancet (1989) [Pubmed]
  19. Activation of the alternative complement pathway accompanies disease flares in systemic lupus erythematosus during pregnancy. Buyon, J.P., Tamerius, J., Ordorica, S., Young, B., Abramson, S.B. Arthritis Rheum. (1992) [Pubmed]
  20. Preeclampsia is associated with failure of human cytotrophoblasts to mimic a vascular adhesion phenotype. One cause of defective endovascular invasion in this syndrome? Zhou, Y., Damsky, C.H., Fisher, S.J. J. Clin. Invest. (1997) [Pubmed]
  21. Prostacyclin activity in amniotic fluid in pre-eclampsia. Bodzenta, A., Thomson, J.M., Poller, L. Lancet (1980) [Pubmed]
  22. Impacts of a new transcription factor family: mammalian GCM proteins in health and disease. Hashemolhosseini, S., Wegner, M. J. Cell Biol. (2004) [Pubmed]
  23. Id-2 regulates critical aspects of human cytotrophoblast differentiation, invasion and migration. Janatpour, M.J., McMaster, M.T., Genbacev, O., Zhou, Y., Dong, J., Cross, J.C., Israel, M.A., Fisher, S.J. Development (2000) [Pubmed]
  24. Plasma from women with preeclampsia increases endothelial cell nitric oxide production. Baker, P.N., Davidge, S.T., Roberts, J.M. Hypertension (1995) [Pubmed]
  25. Combinations of maternal KIR and fetal HLA-C genes influence the risk of preeclampsia and reproductive success. Hiby, S.E., Walker, J.J., O'shaughnessy, K.M., Redman, C.W., Carrington, M., Trowsdale, J., Moffett, A. J. Exp. Med. (2004) [Pubmed]
  26. Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. Maynard, S.E., Min, J.Y., Merchan, J., Lim, K.H., Li, J., Mondal, S., Libermann, T.A., Morgan, J.P., Sellke, F.W., Stillman, I.E., Epstein, F.H., Sukhatme, V.P., Karumanchi, S.A. J. Clin. Invest. (2003) [Pubmed]
  27. Human trophoblast survival at low oxygen concentrations requires metalloproteinase-mediated shedding of heparin-binding EGF-like growth factor. Armant, D.R., Kilburn, B.A., Petkova, A., Edwin, S.S., Duniec-Dmuchowski, Z.M., Edwards, H.J., Romero, R., Leach, R.E. Development (2006) [Pubmed]
  28. Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis. Shibuya, M., Claesson-Welsh, L. Exp. Cell Res. (2006) [Pubmed]
  29. Preeclampsia is associated with impaired regulation of the placental nitric oxide-cyclic guanosine monophosphate pathway by corticotropin-releasing hormone (CRH) and CRH-related peptides. Karteris, E., Vatish, M., Hillhouse, E.W., Grammatopoulos, D.K. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  30. Reduced expression of corticotropin-releasing hormone receptor type-1 alpha in human preeclamptic and growth-restricted placentas. Karteris, E., Goumenou, A., Koumantakis, E., Hillhouse, E.W., Grammatopoulos, D.K. J. Clin. Endocrinol. Metab. (2003) [Pubmed]
  31. Fibrinolytic activity and protein C in preeclampsia. Aznar, J., Gilabert, J., Estellés, A., España, F. Thromb. Haemost. (1986) [Pubmed]
  32. Prothrombotic genotypes are not associated with pre-eclampsia and gestational hypertension: results from a large population-based study and systematic review. Morrison, E.R., Miedzybrodzka, Z.H., Campbell, D.M., Haites, N.E., Wilson, B.J., Watson, M.S., Greaves, M., Vickers, M.A. Thromb. Haemost. (2002) [Pubmed]
  33. Pitfalls in the measurement of circulating vascular endothelial growth factor. Jelkmann, W. Clin. Chem. (2001) [Pubmed]
  34. Cord plasma vasopressin, erythropoietin, and hypoxanthine as indices of asphyxia at birth. Ruth, V., Fyhrquist, F., Clemons, G., Raivio, K.O. Pediatr. Res. (1988) [Pubmed]
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