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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Clorazepate and lorazepam: clinical improvement and rebound anxiety.

Sixty-two anxious patients were treated under double-blind conditions for 4 weeks with either clorazepate or lorazepam. Two-thirds of each treatment group were then switched abruptly to placebo for 2 weeks, while one-third continued to receive active medication. Two major findings were obtained. About 70% of the patients maintained improvement during the 2-week placebo period. Some patients, however, experienced rebound anxiety, which appeared to be more intense and occurred earlier when placebo was substituted for a benzodiazepine with a short half-life (lorazepam) than for one with a long half-life (clorazepate). The clinical relevance of these findings is discussed.[1]

References

  1. Clorazepate and lorazepam: clinical improvement and rebound anxiety. Rickels, K., Fox, I.L., Greenblatt, D.J., Sandler, K.R., Schless, A. The American journal of psychiatry. (1988) [Pubmed]
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