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Chemical Compound Review

Tranxene     10-chloro-5-oxo-2-phenyl- 3,6...

Synonyms: clorazepate, Chlorazepate, Gen-xene, Novo-Clopate, CHEBI:3761, ...
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Disease relevance of Chlorazepate


Psychiatry related information on Chlorazepate


High impact information on Chlorazepate


Chemical compound and disease context of Chlorazepate


Biological context of Chlorazepate

  • Clorazepate kinetics in treated epileptics [19].
  • Desmethyldiazepam pharmacokinetics were determined after oral administration of its precursor, clorazepate, to 12 obese subjects (mean weight: 105.4 kg; mean percent ideal body weight: 170%) who were matched for age, sex, and smoking habits with 12 normal controls (66.5 kg; percent ideal body weight: 103.3%) [4].
  • The assay was used in a comparative bioavailability study of single equimolar oral doses of monopotassium and dipotassium salts of clorazepate in dogs [20].
  • Release of cells from a 48 h exposure to 350 microM clorazepate, at which over 70% of the cells were arrested, resulted in a synchronous entry into S phase 8-9 h later, as evidenced by a sharp increase in the incorporation of [3H]thymidine [5].
  • Clorazepate inhibited C6 proliferation in a dose-dependent manner with an IC50 value of 280 microM, as judged by a nuclei counting procedure [5].

Anatomical context of Chlorazepate


Associations of Chlorazepate with other chemical compounds


Gene context of Chlorazepate

  • The non-enantioselective interactions of benzoin and benzodiazepines except for clorazepate with BSA fragments were increased with protein surface coverages, while those of 2-arylpropionic acid, clorazepate and warfarin were decreased [27].
  • Clorazepate proved the more effective drug, as shown by a reduction in total symptom scale of Kellner Symptom Rating Test and the reduction in sub-scales for anxiety, depression, somatic complaints and general neurotic symptoms with parallel symptom reduction in linear analogue scales [28].

Analytical, diagnostic and therapeutic context of Chlorazepate


  1. Clorazepate and phenobarbital as antiepileptic drugs: a double-blind study. Wilensky, A.J., Ojemann, L.M., Temkin, N.R., Troupin, A.S., Dodrill, C.B. Neurology (1981) [Pubmed]
  2. Action of psychoactive drugs on sex-related differences of OF1 mice; intraspecific aggressiveness and acute hypoxia survival. Stupfel, M., Massé, H., Dague, C. Psychopharmacology (Berl.) (1979) [Pubmed]
  3. Effects of clorazepate on breathlessness and exercise tolerance in patients with chronic airflow obstruction. Eimer, M., Cable, T., Gal, P., Rothenberger, L.A., McCue, J.D. The Journal of family practice. (1985) [Pubmed]
  4. Prolongation of drug half-life due to obesity: studies of desmethyldiazepam (clorazepate). Abernethy, D.R., Greenblatt, D.J., Divoll, M., Shader, R.I. Journal of pharmaceutical sciences. (1982) [Pubmed]
  5. Clorazepate synchronizes cultured rat C6 glioma in the early G1 phase of the cell cycle. Maguire, C., O'Connell, C., Regan, C.M. Brain Res. (1992) [Pubmed]
  6. Topographic EEG changes with benzodiazepine administration in generalized anxiety disorder. Buchsbaum, M.S., Hazlett, E., Sicotte, N., Stein, M., Wu, J., Zetin, M. Biol. Psychiatry (1985) [Pubmed]
  7. Depressive symptoms and intellectual functioning in anxiety patients treated with clorazepate. Fabre, L.F., Putman, H.P. The Journal of clinical psychiatry. (1988) [Pubmed]
  8. Delayed maze-learning in rats after prenatal exposure to clorazepate. Pascuzzi Jackson, V., DeMyer, W., Hingtgen, J. Arch. Neurol. (1980) [Pubmed]
  9. Buspirone in the treatment of panic disorder: a controlled pilot comparison with clorazepate. Schweizer, E., Rickels, K. Journal of clinical psychopharmacology. (1988) [Pubmed]
  10. Anxiolytic properties of agomelatine, an antidepressant with melatoninergic and serotonergic properties: role of 5-HT2C receptor blockade. Millan, M.J., Brocco, M., Gobert, A., Dekeyne, A. Psychopharmacology (Berl.) (2005) [Pubmed]
  11. Clorazepate in epilepsy. Livingston, S., Pauli, L.L. JAMA (1977) [Pubmed]
  12. Clorazepate and lorazepam: clinical improvement and rebound anxiety. Rickels, K., Fox, I.L., Greenblatt, D.J., Sandler, K.R., Schless, A. The American journal of psychiatry. (1988) [Pubmed]
  13. Double-blind comparison of buspirone and clorazepate in anxious outpatients. Cohn, J.B., Bowden, C.L., Fisher, J.G., Rodos, J.J. Am. J. Med. (1986) [Pubmed]
  14. Effect of age and Billroth gastrectomy on absorption of desmethyldiazepam from clorazepate. Ochs, H.R., Greenblatt, D.J., Allen, M.D., Harmatz, J.S., Shader, R.I., Bodem, G. Clin. Pharmacol. Ther. (1979) [Pubmed]
  15. Evaluation of clorazepate (Tranxene) as an anticonvulsant--a pilot study. Troupin, A.S., Friel, P., Wilensky, A.J., Morretti-Ojemann, L., Levy, R.H., Feigl, P. Neurology (1979) [Pubmed]
  16. Xylazine in human tissue and fluids in a case of fatal drug abuse. Poklis, A., Mackell, M.A., Case, M.E. Journal of analytical toxicology. (1985) [Pubmed]
  17. Comparative study of the efficacy and safety of trazodone versus clorazepate in the treatment of adjustment disorders in cancer patients: a pilot study. Razavi, D., Kormoss, N., Collard, A., Farvacques, C., Delvaux, N. J. Int. Med. Res. (1999) [Pubmed]
  18. Inhibition of lipid peroxidation in rat brain by nifedipine and clorazepate after electrically induced seizures. Kułak, W., Sobaniec, W., Sobaniec-Lotowska, M. Materia medica Polona. Polish journal of medicine and pharmacy. (1993) [Pubmed]
  19. Clorazepate kinetics in treated epileptics. Wilensky, A.J., Levy, R.H., Troupin, A.S., Moretti-Ojemann, L. Clin. Pharmacol. Ther. (1978) [Pubmed]
  20. GLC determination of plasma drug levels after oral administration of clorazepate potassium salts. Hoffman, D.J., Chun, A.H. Journal of pharmaceutical sciences. (1975) [Pubmed]
  21. In vitro effect of benzodiazepines on polymorphonuclear leukocyte oxidative activity. Goldfarb, G., Belghiti, J., Gautero, H., Boivin, P. Anesthesiology (1984) [Pubmed]
  22. S-16924 [(R)-2-[1-[2-(2,3-dihydro-benzo[1,4]dioxin-5-yloxy)-ethyl]- pyrrolidin-3yl]-1-(4-fluorophenyl)-ethanone], a novel, potential antipsychotic with marked serotonin1A agonist properties: III. Anxiolytic actions in comparison with clozapine and haloperidol. Millan, M.J., Brocco, M., Gobert, A., Schreiber, R., Dekeyne, A. J. Pharmacol. Exp. Ther. (1999) [Pubmed]
  23. Behavioural and pharmacokinetic studies in the monkey (Macaca mulatta) with diazepam, nordiazepam and related 1,4-benzodiazepines. Curry, S.H., Whelpton, R., Nicholson, A.N., Wright, C.M. Br. J. Pharmacol. (1977) [Pubmed]
  24. Impact of tracheotomy on sedative administration, sedation level, and comfort of mechanically ventilated intensive care unit patients. Nieszkowska, A., Combes, A., Luyt, C.E., Ksibi, H., Trouillet, J.L., Gibert, C., Chastre, J. Crit. Care Med. (2005) [Pubmed]
  25. Individual variations in the effects of flurazepam, clorazepate, L-dopa and thyrotropin-releasing hormone on REM sleep in man. Nakazawa, Y., Kotorii, T., Horikawa, S., Kotorii, M., Ohshima, M., Hasuzawa, H. Psychopharmacology (Berl.) (1979) [Pubmed]
  26. Comparative single-dose kinetics of oxazolam, prazepam, and clorazepate: three precursors of desmethyldiazepam. Ochs, H.R., Greenblatt, D.J., Verburg-Ochs, B., Locniskar, A. Journal of clinical pharmacology. (1984) [Pubmed]
  27. Enantioselectivity of bovine serum albumin-bonded columns produced with isolated protein fragments. II. Characterization of protein fragments and chiral binding sites. Haginaka, J., Kanasugi, N. Journal of chromatography. A. (1997) [Pubmed]
  28. Value of a single night-time dose of potassium clorazepate in anxiety: a controlled trial comparison with diazepam. Henderson, J.G. Scottish medical journal. (1982) [Pubmed]
  29. Determination of clorazepate and its major metabolites in blood and urine by electron capture gas-liquid chromatography. Brooks, M.A., Hackman, M.R., Weinfeld, R.E., Macasieb, T. J. Chromatogr. (1977) [Pubmed]
  30. Effect of clorazepate in spasticity and rigidity: a quantitative study of reflexes and plasma concentrations. Lossius, R., Dietrichson, P., Lunde, P.K. Acta neurologica Scandinavica. (1985) [Pubmed]
  31. Disposition of clorazepate in dogs after single- and multiple-dose oral administration. Forrester, S.D., Brown, S.A., Lees, G.E., Hartsfield, S.M. Am. J. Vet. Res. (1990) [Pubmed]
  32. Effects of serum separation tubes on serum benzodiazepine and phenobarbital concentrations in clinically normal and epileptic dogs. Boothe, D.M., Simpson, G., Foster, T. Am. J. Vet. Res. (1996) [Pubmed]
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