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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The clam embryo protein cyclin A induces entry into M phase and the resumption of meiosis in Xenopus oocytes.

Fertilized clam embryos synthesize several new cell-cycle-related proteins. The cloned cDNA and derived amino acid sequences of one of these, cyclin A, are presented here. Immunoblots with an anti-cyclin A antibody reveal that cyclin A is undetectable in oocytes, appears within 15 min of fertilization, and is destroyed near the end of each meiosis and mitosis. We directly tested the ability of cyclin A to induce M phase by injecting SP6 cyclin A mRNA into Xenopus oocytes, which are arrested at the G2/M border of first meiosis. The injected mRNA was translated, with the result that the Xenopus oocytes entered meiosis. These findings indicate that the rise in cyclin A plays a direct and natural role in driving cells into M phase.[1]

References

  1. The clam embryo protein cyclin A induces entry into M phase and the resumption of meiosis in Xenopus oocytes. Swenson, K.I., Farrell, K.M., Ruderman, J.V. Cell (1986) [Pubmed]
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