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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Factor XIII (fibrin stabilising factor) in Henoch-Schönlein's purpura.

In 13 out of 17 consecutive children with Henoch-Schönlein's purpura the factor XIII determined with the dansyl cadaverine method was found to be decreased during the acute phase. The decrease is assumed to be due to a specific degradation by proteolytic enzymes liberated from inflammatory cells, with defective local haemostasis as a result. This assumption is strengthened by the observation that treatment with factor XIII combined with an antifibrinolytic drug controlled life-threatening gastro-intestinal bleeding in one of the patients. It would therefore appear that such treatment might offer a new possibility of controlling severe haemorrhages in Henoch-Schönlein's purpura.[1]

References

  1. Factor XIII (fibrin stabilising factor) in Henoch-Schönlein's purpura. Henriksson, P., Hedner, U., Nilsson, I.M. Acta paediatrica Scandinavica. (1977) [Pubmed]
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