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MeSH Review


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Disease relevance of Purpura


High impact information on Purpura


Chemical compound and disease context of Purpura

  • When posttransfusion purpura serum was studied, antibody binding to the PlA1 antigen on glycoprotein IIIa was readily distinguished from the nonspecific binding of immunoglobulin to a protein of 200,000 mol wt [11].
  • Use of protein-C concentrate, heparin, and haemodiafiltration in meningococcus-induced purpura fulminans [12].
  • Coumarin prophylaxis for fulminant purpura syndrome due to homozygous protein C deficiency [13].
  • Adult Schönlein-Henoch purpura after enalapril [14].
  • Adult Schönlein-Henoch purpura after lisinopril [15].

Biological context of Purpura

  • In patients with immune thrombocytopenia purpura (ITP), with decreased PLT survival, but intact bone marrow megakaryocytopoiesis, endogenous IL-11 levels were significantly increased (328.0 +/- 92.6 pg/mL, [PLT: 20,900 +/- 3,000/microL], P < .05, n = 25) [16].
  • We present 2 children from 2 unrelated Arab families with purpura fulminans who were double heterozygotes for factor V Leiden inherited from their fathers and protein S deficiency inherited from their mothers [17].
  • Thus, in individuals with severe disease expression, the risk of purpura fulminans with death or deformity was significantly increased when the platelet count was < 50,000 cells/mm3 (P = .0001) and protein C levels were low (P = .0158) [18].
  • Abnormalities of immunoglobulin A1 (IgA1) glycosylation have been described in patients with IgA nephropathy (IgAN), whether primitive or secondary to Henoch-Schönlein purpura [19].
  • Posttransfusion purpura: conversion of PLA1-negative platelets to the PLA1-positive phenotype by stored plasma is not due to the presence of soluble PLA1 antigen [20].

Anatomical context of Purpura

  • ACTH-secreting medullary carcinoma of the thyroid presenting a severe idiopathic osteoporosis and senile purpura: report of a case and review of the literature [21].
  • To investigate the role of human hepatocyte growth factor (hHGF) in vascular lesions associated with endothelial injury, we measured serum hHGF concentrations in subjects with retinal arteriosclerosis, coronary atherosclerosis, or arteriolitis due to Henoch-Schönlein purpura [22].
  • 2. Dexamethasone treatment (0.4-4 mg kg-1, daily for 1-6 days) produced time- and dose-dependent damage to the glandular mucosa of the stomach as characterized by extensive, uniform hyperaemia with multiple, focal petechiae and erosions [23].
  • A latex assay revealed the CS index (CSI) was significantly low in patients with podocyte disease (group A), including SSNS, focal and segmental glomerulosclerosis (FSGS) and Finnish-type congenital nephrotic syndrome (FCNS), but high in those with Alport syndrome (AS), IgAN, Henoch-Schönlein purpura nephritis (HSPN), and MPGN (group B) [24].
  • The episodes of purpura fulminans were controlled by infusions of fresh frozen plasma containing protein C. The requirement of frequent plasma infusions, however, eventually resulted in several complications secondary to hyperproteinemia [25].

Gene context of Purpura


Analytical, diagnostic and therapeutic context of Purpura


  1. Dilantin-induced disseminated intravascular coagulation with purpura fulminans. A case report. Targan, S.R., Chassin, M.R., Guze, L.B. Ann. Intern. Med. (1975) [Pubmed]
  2. IVIg-mediated amelioration of murine ITP via FcgammaRIIB is independent of SHIP1, SHP-1, and Btk activity. Crow, A.R., Song, S., Freedman, J., Helgason, C.D., Humphries, R.K., Siminovitch, K.A., Lazarus, A.H. Blood (2003) [Pubmed]
  3. Application of the enzyme linked immunospecific assay (ELISA) for the detection of platelet antibodies. Gudino, M., Miller, W.V. Blood (1981) [Pubmed]
  4. Diagnosis and management of disseminated intravascular coagulation: the role of heparin therapy. Feinstein, D.I. Blood (1982) [Pubmed]
  5. Human thrombopoietin levels are high when thrombocytopenia is due to megakaryocyte deficiency and low when due to increased platelet destruction. Emmons, R.V., Reid, D.M., Cohen, R.L., Meng, G., Young, N.S., Dunbar, C.E., Shulman, N.R. Blood (1996) [Pubmed]
  6. Treatment of homozygous protein C deficiency and neonatal purpura fulminans with a purified protein C concentrate. Dreyfus, M., Magny, J.F., Bridey, F., Schwarz, H.P., Planché, C., Dehan, M., Tchernia, G. N. Engl. J. Med. (1991) [Pubmed]
  7. Purpura due to ethanol. Alibrandi, B., Parodi, A., Varaldo, G. N. Engl. J. Med. (1990) [Pubmed]
  8. Tumor necrosis factor and interleukin-1 in the serum of children with severe infectious purpura. Girardin, E., Grau, G.E., Dayer, J.M., Roux-Lombard, P., Lambert, P.H. N. Engl. J. Med. (1988) [Pubmed]
  9. Purpura due to inhaled quinidine. Salom, I.L. JAMA (1991) [Pubmed]
  10. Prophylaxis of steroid-induced purpura. Bernhard, J.D. JAMA (1990) [Pubmed]
  11. Platelet membrane glycoprotein IIIa contains target antigens that bind anti-platelet antibodies in immune thrombocytopenias. Beardsley, D.S., Spiegel, J.E., Jacobs, M.M., Handin, R.I., Lux, S.E. J. Clin. Invest. (1984) [Pubmed]
  12. Use of protein-C concentrate, heparin, and haemodiafiltration in meningococcus-induced purpura fulminans. Smith, O.P., White, B., Vaughan, D., Rafferty, M., Claffey, L., Lyons, B., Casey, W. Lancet (1997) [Pubmed]
  13. Coumarin prophylaxis for fulminant purpura syndrome due to homozygous protein C deficiency. Garcia-Plaza, I., Jimenez-Astorga, C., Borrego, D., Marty, M.L. Lancet (1985) [Pubmed]
  14. Adult Schönlein-Henoch purpura after enalapril. Moots, R.J., Keeling, P.J., Morgan, S.H. Lancet (1992) [Pubmed]
  15. Adult Schönlein-Henoch purpura after lisinopril. Disdier, P., Harlé, J.R., Verrot, D., Jouglard, J., Weiller, P.J. Lancet (1992) [Pubmed]
  16. Differential mechanisms in the regulation of endogenous levels of thrombopoietin and interleukin-11 during thrombocytopenia: insight into the regulation of platelet production. Chang, M., Suen, Y., Meng, G., Buzby, J.S., Bussel, J., Shen, V., van de Ven, C., Cairo, M.S. Blood (1996) [Pubmed]
  17. Purpura fulminans induced by disseminated intravascular coagulation following infection in 2 unrelated children with double heterozygosity for factor V Leiden and protein S deficiency. Inbal, A., Kenet, G., Zivelin, A., Yermiyahu, T., Bronstein, T., Sheinfeld, T., Tamari, H., Gitel, S., Eshel, G., Duchemin, J., Aiach, M., Seligsohn, U. Thromb. Haemost. (1997) [Pubmed]
  18. Epidemic meningococcemia and purpura fulminans with induced protein C deficiency. Powars, D., Larsen, R., Johnson, J., Hulbert, T., Sun, T., Patch, M.J., Francis, R., Chan, L. Clin. Infect. Dis. (1993) [Pubmed]
  19. Henoch-Schönlein purpura with immunoglobulin A nephropathy and abnormalities of immunoglobulin A in a Wiskott-Aldrich syndrome carrier. Lasseur, C., Allen, A.C., Deminière, C., Aparicio, M., Feehally, J., Combe, C. Am. J. Kidney Dis. (1997) [Pubmed]
  20. Posttransfusion purpura: conversion of PLA1-negative platelets to the PLA1-positive phenotype by stored plasma is not due to the presence of soluble PLA1 antigen. Ehmann, W.C., Dancis, A., Ferziger, R., Karpatkin, S. Proc. Soc. Exp. Biol. Med. (1990) [Pubmed]
  21. ACTH-secreting medullary carcinoma of the thyroid presenting a severe idiopathic osteoporosis and senile purpura: report of a case and review of the literature. Rosenberg, E.M., Hahn, T.J., Orth, D.N., Deftos, L.J., Tanaka, K. J. Clin. Endocrinol. Metab. (1978) [Pubmed]
  22. Serum hepatocyte growth factor as a possible indicator of vascular lesions. Nishimura, M., Ushiyama, M., Ohtsuka, K., Nishida, M., Inoue, N., Matsumuro, A., Mineo, T., Yoshimura, M. J. Clin. Endocrinol. Metab. (1999) [Pubmed]
  23. Dexamethasone-induced gastric mucosal damage in the rat: possible role of platelet-activating factor. Filep, J.G., Hermán, F., Földes-Filep, E., Schneider, F., Braquet, P. Br. J. Pharmacol. (1992) [Pubmed]
  24. Charge selective function in childhood glomerular diseases. Takahashi, S., Watanabe, S., Wada, N., Murakami, H., Funaki, S., Yan, K., Kondo, Y., Harada, K., Nagata, M. Pediatr. Res. (2006) [Pubmed]
  25. Severe homozygous protein C deficiency. Sills, R.H., Marlar, R.A., Montgomery, R.R., Deshpande, G.N., Humbert, J.R. J. Pediatr. (1984) [Pubmed]
  26. Evaluation of ADAMTS-13 activity in plasma using recombinant von Willebrand Factor A2 domain polypeptide as substrate. Cruz, M.A., Whitelock, J., Dong, J.F. Thromb. Haemost. (2003) [Pubmed]
  27. Postinfectious purpura fulminans caused by an autoantibody directed against protein S. Levin, M., Eley, B.S., Louis, J., Cohen, H., Young, L., Heyderman, R.S. J. Pediatr. (1995) [Pubmed]
  28. Matrix metalloproteinase 9 (MMP-9) gene polymorphism and MMP-9 plasma levels in primary Sjogren's syndrome. Hulkkonen, J., Pertovaara, M., Antonen, J., Pasternack, A., Hurme, M., Pöllänen, P., Lehtimäki, T. Rheumatology (Oxford, England) (2004) [Pubmed]
  29. Th2 cytokine genotypes are associated with a milder form of primary Sjogren's syndrome. Pertovaara, M., Antonen, J., Hurme, M. Ann. Rheum. Dis. (2006) [Pubmed]
  30. Coumarin necrosis, neonatal purpura fulminans, and protein C deficiency. Gladson, C.L., Groncy, P., Griffin, J.H. Archives of dermatology. (1987) [Pubmed]
  31. Thrombotic thrombocytopenic purpura: combined treatment with plasmapheresis and antiplatelet agents. Myers, T.J., Wakem, C.J., Ball, E.D., Tremont, S.J. Ann. Intern. Med. (1980) [Pubmed]
  32. Drug purpura due to surreptitious quinidine intake. Reid, D.M., Shulman, N.R. Ann. Intern. Med. (1988) [Pubmed]
  33. The clinical course of IgA-nephropathy and Henoch-Schönlein purpura following renal transplantation. Bachman, U., Biava, C., Amend, W., Feduska, N., Melzer, J., Salvatierra, O., Vincenti, F. Transplantation (1986) [Pubmed]
  34. Topical nitroglycerin and pain in purpura fulminans. Meyer, M.T., Irazuzta, J.E., Tozibikian, H. J. Pediatr. (1999) [Pubmed]
  35. Case report and review of resolved fusariosis. Helm, T.N., Longworth, D.L., Hall, G.S., Bolwell, B.J., Fernandez, B., Tomecki, K.J. J. Am. Acad. Dermatol. (1990) [Pubmed]
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