Messenger RNA encoding the phosphoprotein ( P) gene of human parainfluenza virus 3 is bicistronic.
The complete nucleotide sequence of the phosphoprotein ( P) mRNA of human parainfluenza virus 3 (PIV-3) was derived from two cDNA clones spanning almost the entire P gene. The mRNA, excluding the poly(A) tail, is 2014 nucleotides long and is bicistronic. The first open reading frame (ORF) codes for the phosphoprotein ( P) of mol wt 68,860. Seven nucleotides downstream from the first AUG codon, in a +1 reading frame, there is an additional ORF which can code for a polypeptide of mol wt 23,266. The latter protein appears to be similar to the C proteins found in cells infected with several paramyxoviruses. Comparison of the predicted amino acid sequence of the P and C proteins of PIV-3 with the corresponding Sendai virus proteins reveals considerable homology at the C-terminal half. In contrast, the P and C proteins of PIV-3 share very little homology with the measles virus P and C proteins, respectively.[1]References
- Messenger RNA encoding the phosphoprotein (P) gene of human parainfluenza virus 3 is bicistronic. Luk, D., Sánchez, A., Banerjee, A.K. Virology (1986) [Pubmed]
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