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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The determination of mineralocorticoid receptors in human mononuclear leukocytes from patients with mineralocorticoid excess: physiological and pathological implications.

The affinity and the capacity of mineralocorticoid receptors ( MR) in human mononuclear leukocytes (HML) were determined in 9 patients with Conn's syndrome (PA) and in 3 patients with pseudohypoaldosteronism (PHA). The number of binding sites per cell was 136 +/- 39 (mean +/- SD) in PA. One case with PHA had no MR, and of the other 2 patients, one had 50 and the other 55 receptors per cell. The capacity of normal controls ranged from 200 to 400 receptors per cell (n = 20). We conclude that the etiology of PHA is due to a lack of MR in the target tissues and that a down regulation of MR may exist in PA.[1]

References

  1. The determination of mineralocorticoid receptors in human mononuclear leukocytes from patients with mineralocorticoid excess: physiological and pathological implications. Armanini, D., Kuhnle, U., Witzgall, H., Tietze, U., Saule, H., Schroeter, C., Strasser, T., Butenandt, I., Bidlingmaier, F., Weber, P.C. Clinical and experimental hypertension. Part A, Theory and practice. (1986) [Pubmed]
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