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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

The mRNA and RNA-copy pseudogenes encoding TM30nm, a human cytoskeletal tropomyosin.

We have determined the sequence of a 2.5 kb mRNA in human fibroblasts encoding a 248 amino acid cytoskeletal tropomyosin. The protein product of this mRNA is TM30nm, one of five tropomyosin-like proteins in human fibroblasts. The structural gene encoding this mRNA can also produce a 1.3 kb mRNA encoding a 285 amino acid skeletal muscle alpha-tropomyosin by tissue-specific alternative mRNA splicing. However, the multiple RNA-copy pseudogenes of this gene family are derived largely if not exclusively from transcripts processed according to the pattern observed in non-muscle cells.[1]

References

  1. The mRNA and RNA-copy pseudogenes encoding TM30nm, a human cytoskeletal tropomyosin. MacLeod, A.R., Houlker, C., Reinach, F.C., Talbot, K. Nucleic Acids Res. (1986) [Pubmed]
 
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