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Gene Review:

LOC146253 - tropomyosin 3 pseudogene

Homo sapiens

Bikle, D.D. et al., Bourguignon, L.Y. et al., Song, J. et al., Stastny, J.J. et al., Giometti, C.S. et al., et al.

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High impact information on LOC146253

Zipper protein, a newly described tropomyosin-like protein of the intestinal brush border [1].
We have cloned and sequenced from a chick intestinal library the cDNA for a new tropomyosin-like protein with an extensive leucine zipper motif [1].
We conclude that zipper protein is a tropomyosin-like protein found predominantly in the intestinal brush border; its location and structural similarity to tropomyosin suggest a possible role in regulating the interaction of brush border myosin 1 with the actin core of the microvillus [1].
The nonmuscle tropomyosin-like proteins were compared with tropomysins from human skeletal, cardiac, and smooth muscle by peptide mapping after partial proteolysis [2].
The protein product of this mRNA is TM30nm, one of five tropomyosin-like proteins in human fibroblasts [3].

Biological context of LOC146253

Phosphorylation of a tropomyosin-like (30 KD) protein during platelet activation [4].

Anatomical context of LOC146253

Proteins which are typically found intracellularly such as those from groups 11 (actin), 12 (cytoskeleton proteins), and 13 (tropomyosin-like proteins) appeared in samples of intima of both age groups but were less apparent in older specimens [5].

Associations of LOC146253 with chemical compounds

The vascular-origin proteins actin, tropomyosin-like proteins, tubulin, glycoprotein G35, and two myosin light chains were present in the highest amounts in normal aortic intima (27-year-old male) [6].

Analytical, diagnostic and therapeutic context of LOC146253

Further analysis using both standard two-dimensional gel electrophoresis and one-dimensional urea-SDS gel electrophoresis reveals that this 30 KD protein has several tropomyosin-like properties [4].

References

Zipper protein, a newly described tropomyosin-like protein of the intestinal brush border. Bikle, D.D., Munson, S., Morrison, N., Eisman, J. J. Biol. Chem. (1993) [Pubmed]
Tropomyosin heterogeneity in human cells. Giometti, C.S., Anderson, N.L. J. Biol. Chem. (1984) [Pubmed]
The mRNA and RNA-copy pseudogenes encoding TM30nm, a human cytoskeletal tropomyosin. MacLeod, A.R., Houlker, C., Reinach, F.C., Talbot, K. Nucleic Acids Res. (1986) [Pubmed]
Phosphorylation of a tropomyosin-like (30 KD) protein during platelet activation. Bourguignon, L.Y., Field, S., Bourguignon, G.J. J. Cell. Biochem. (1985) [Pubmed]
Effect of aging on human aortic protein composition. II. Two-dimensional polyacrylamide gel electrophoretic analysis. Song, J., Stastny, J., Fosslien, E., Robertson, A.L. Exp. Mol. Pathol. (1985) [Pubmed]
Quantitative alteration of some aortic intima proteins in fatty streaks and fibro-fatty lesions. Stastny, J.J., Fosslien, E. Exp. Mol. Pathol. (1992) [Pubmed]

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