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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Avian sarcoma virus 17 carries the jun oncogene.

Biologically active molecular clones of avian sarcoma virus 17 ( ASV 17) contain a replication-defective proviral genome of 3.5 kilobases (kb). The genome retains partial gag and env sequences, which flank a cell-derived putative oncogene of 0.93 kb, termed jun. The jun gene lacks preserved coding domains of tyrosine-specific protein kinases. It also shows no significant nucleic acid homology with other known oncogenes. The probable transformation-specific protein in ASV 17-transformed cells is a 55-kDa gag-jun fusion product.[1]

References

  1. Avian sarcoma virus 17 carries the jun oncogene. Maki, Y., Bos, T.J., Davis, C., Starbuck, M., Vogt, P.K. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
 
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