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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Stereospecific acute neuronotoxicity of 'uncommon' plant amino acids linked to human motor-system diseases.

The L-isomer of beta-N-methylamino-L-alanine (BMAA), present in free form in seed of Cycas circinalis, elicits in spinal cord cultures a pattern of acute postsynaptic neuronal vacuolation comparable to that induced by beta-N-oxalylamino-L-alanine (BOAA), an excitotoxic amino acid of greater potency isolated from seed of Lathyrus sativus. The neuronotoxic properties of these compounds may be linked to the etiology of motor-system degenerative disorders (amyotrophic lateral sclerosis and lathyrism, respectively) found in human groups that have used these plant seeds for food.[1]

References

  1. Stereospecific acute neuronotoxicity of 'uncommon' plant amino acids linked to human motor-system diseases. Nunn, P.B., Seelig, M., Zagoren, J.C., Spencer, P.S. Brain Res. (1987) [Pubmed]
 
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