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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Acute leukemia. Learning disabilities following CNS irradiation.

Thirteen elementary school age children with acute leukemia who had received cranial irradiation with dosages between 1,800 and 4,800 rads a mean of 6.3 years earlier were evaluated for the presence of learning disorders. The authors utilized both psychometric and educational tests. The results were analyzed according to a graduated regressed standard score procedure and yielded the following diagnoses: mental retardation, two (15%); learning disability in reading and mathematics, two (15%); learning disability in mathematics, five (39%); no psychoeducational diagnosis, four (31%). Of the nine children (69%) who qualified for a specific psychoeducational diagnosis, only three were receiving any special educational services. The failure of a previous assessment of this same group of children at our center and of other research reports to uncover a similarly high incidence of neurodevelopmental pathology may be due to the specific tests employed or to the later onset of measurable difficulties in these patients.[1]


  1. Acute leukemia. Learning disabilities following CNS irradiation. Fogarty, K., Volonino, V., Caul, J., Rongey, J., Whitman, B., O'Connor, D., Accardo, P. Clinical pediatrics. (1988) [Pubmed]
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