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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Psychometrics


Psychiatry related information on Psychometrics

  • Methylphenidate effects in learning disabilities. Psychometric changes [6].
  • Therefore, we performed a study to assess the clinical features and the survival of cirrhotic patients with cognitive alterations detected by the number connection test (NCT) and a set of computerized psychometric tests (Scan, Choice1, and Choice2) measuring the reaction times and the percentage of errors in performing specific tasks [7].
  • Genetically determined Alzheimer's disease (AD) is virtually unknown in Africa. We report clinicopathological findings and a presenilin 1 (PS1) mutation associated with early-onset AD in a large Xhosa family from Southern Africa. Twelve individuals spanning four generations were affected, four of whom underwent clinical and psychometric evaluation [8].
  • The author tested the entire population (N = 42) of the Hare Krishna Temple in Melbourne on the MMPI, the General Health Questionnaire, and the Eysenck Personality Questionnaire psychometric indices and then randomly selected 6 subjects to take the Present State Examination [9].
  • RESEARCH DESIGN AND METHODS: Detailed psychometric assessment, especially memory testing, performed with MRI in a man with severe amnesia after hypoglycemic coma [10].

High impact information on Psychometrics

  • Abnormal P300 test results were also found in 78% of the clinically nonencephalopathic cirrhotics, while psychometric tests showed abnormalities in only 41% [11].
  • Here we describe genetic and psychometric testing of patients who have small deletions within the WS critical region [12].
  • Additionally, standard psychometric tests (Trail Making Test A, Mini-Mental State Examination, and Profile of Mood State test) were performed [13].
  • HE evaluation included psychometric performance (Trail-Making Test A), electroencephalogram (EEG), mental status examination and grading, arterial, venous, and partial pressure of ammonia determination [14].
  • In the SHE patients administered lactulose, the results of the quantitative psychometric evaluation were significantly improved at 4 and 8 weeks after the beginning of the lactulose administration [15].

Chemical compound and disease context of Psychometrics

  • We concluded that lactulose treatment in cirrhotic patients with SHE is effective with respect to psychometric tests [15].
  • Psychometric properties of the AIMS2-Short Form (AIMS2-SF) and AIMS2 were compared using data from a cohort of 127 rheumatoid arthritis patients who completed the AIMS2 twice prior to the initiation of methotrexate (MTX) treatment and 3 months post-initiation of MTX treatment [16].
  • The therapeutic effect of buspirone was assessed by standard psychometric rating scales [17].
  • We measured the initial and steady-state effects of diphenhydramine, a first-generation antihistamine, and loratadine, a second-generation antihistamine, by means of a comprehensive battery of psychometric tests that mirror real-world tasks [18].
  • The assessment included magnetic resonance imaging of the brain (including 124 coronal slices of 1.5-mm thickness), psychometric testing, and structured clinical interviews [19].

Biological context of Psychometrics


Anatomical context of Psychometrics

  • Using psychometric scales, 10 patients who had undergone total thyroidectomy for thyroid carcinoma were evaluated for depression, anxiety, and psychomotor slowing; they were examined both when euthyroid and hypothyroid after thyroid hormone withdrawal [25].
  • Improved gait and/or psychometric function was found in four of six NPH vs. none of eight control patients (p < 0.02) after drainage of 40 ml cerebrospinal fluid (CSF tap-test) [26].
  • It was concluded that styrene exposure in industrial environments at moderate or low levels causes central nervous system disturbances which are not always diagnosable with psychometric tests but can be apparent in special otoneurological tests [27].
  • All four subjects with a low red blood cell thiamin level were found to have cerebral atrophy on CT scan and two had psychometric deficits [28].
  • In a double-blind, placebo-controlled study the encephalotropic and psychotropic properties of gabapentin - a new gaba-analogue with anticonvulsant and antispastic properties penetrating the blood brain barrier easily - were studied in 10 normal subjects by means of quantitative pharmaco-EEG and psychometric analyses [29].

Gene context of Psychometrics

  • METHODS: Prolactin (PRL) and cortisol (CORT) responses to the serotonergic agonist d-fenfluramine (D-fen), clinical psychobehavioral changes, and psychometric measures were evaluated 3 weeks and then 12 months after MDMA discontinuation [30].
  • Prolactin (PRL) and growth hormone (GH) responses to the dopaminergic agonist bromocriptine (BROM) and psychometric measures were evaluated 3 weeks after MDMA discontinuation [31].
  • The concentration of sulfatide and albumin ratio correlated inversely with psychometric improvement, whilst VIP and NPY correlated inversely with improvement in alertness [32].
  • We conducted a double-blind placebo-controlled cross-over trial to study the effect of the opiate antagonist, naloxone, on psychometric function together with plasma adrenocorticotrophic hormone (ACTH), cortisol and prolactin [33].
  • Although GH response to GHRH was higher in AD patients than in controls, our results suggest that psychometric discrimination may be more accurate in diagnosis and staging of AD, than in predicting by morphological and hormonal responses [34].

Analytical, diagnostic and therapeutic context of Psychometrics

  • The methodology is applied to five data examples of plasma total cholesterol concentrations, reported height values, dermatoglyphic pattern intensity index scores, measurements of dopamine-beta-hydroxylase activity, and psychometric cognitive test results [35].
  • METHODS: Demented (n = 289) and nondemented (n = 230) individuals enrolled in longitudinal studies at an Alzheimer Disease Research Center received annual clinical and psychometric examinations for up to 20 years [36].
  • METHODS: Ten mildly hypothyroid patients, before and after thyroxine treatment, and 10 healthy controls underwent 99mTc-hexamethylpropyleneamine oxime brain SPECT, MRI, and psychometric testing [37].
  • We investigated the effect of citalopram pretreatment (40 mg iv) on the psychological effects of MDMA (1.5 mg/kg po) in a double-blind placebo-controlled psychometric study in 16 healthy human volunteers [38].
  • OBJECTIVE: The purpose of the present study was to produce an Italian version of the Revised Leeds Disability Questionnaire (LDQ) in a group of patients with ankylosing spondylitis, and to examine the psychometric properties of this version, evaluating its internal consistency, external validity and reliability [39].


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  2. Oral glutamine challenge in cirrhotics pre- and post-liver transplantation: a psychometric and analyzed EEG study. Oppong, K.N., Al-Mardini, H., Thick, M., Record, C.O. Hepatology (1997) [Pubmed]
  3. Effect of L-ornithine-L-aspartate on patients with and without TIPS undergoing glutamine challenge: a double blind, placebo controlled trial. Rees, C.J., Oppong, K., Al Mardini, H., Hudson, M., Record, C.O. Gut (2000) [Pubmed]
  4. Clinical features and changing patterns of neurodegenerative disorders on Guam, 1997-2000. Galasko, D., Salmon, D.P., Craig, U.K., Thal, L.J., Schellenberg, G., Wiederholt, W. Neurology (2002) [Pubmed]
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  6. Methylphenidate effects in learning disabilities. Psychometric changes. Gittleman-Klein, R., Klein, D.F. Arch. Gen. Psychiatry (1976) [Pubmed]
  7. Clinical features and survivial of cirrhotic patients with subclinical cognitive alterations detected by the number connection test and computerized psychometric tests. Amodio, P., Del Piccolo, F., Marchetti, P., Angeli, P., Iemmolo, R., Caregaro, L., Merkel, C., Gerunda, G., Gatta, A. Hepatology (1999) [Pubmed]
  8. Novel presenilin 1 mutation with profound neurofibrillary pathology in an indigenous Southern African family with early-onset Alzheimer's disease. Heckmann, J.M., Low, W.C., de Villiers, C., Rutherfoord, S., Vorster, A., Rao, H., Morris, C.M., Ramesar, R.S., Kalaria, R.N. Brain (2004) [Pubmed]
  9. Clinical profiles of Hare Krishna devotees. Ross, M.W. The American journal of psychiatry. (1983) [Pubmed]
  10. Severe amnesia after hypoglycemia. Clinical, psychometric, and magnetic resonance imaging correlations. Chalmers, J., Risk, M.T., Kean, D.M., Grant, R., Ashworth, B., Campbell, I.W. Diabetes Care (1991) [Pubmed]
  11. Visual event-related P300 potentials in early portosystemic encephalopathy. Kügler, C.F., Lotterer, E., Petter, J., Wensing, G., Taghavy, A., Hahn, E.G., Fleig, W.E. Gastroenterology (1992) [Pubmed]
  12. Williams syndrome: use of chromosomal microdeletions as a tool to dissect cognitive and physical phenotypes. Tassabehji, M., Metcalfe, K., Karmiloff-Smith, A., Carette, M.J., Grant, J., Dennis, N., Reardon, W., Splitt, M., Read, A.P., Donnai, D. Am. J. Hum. Genet. (1999) [Pubmed]
  13. Cyclosporine may affect improvement of cognitive brain function after successful cardiac transplantation. Grimm, M., Yeganehfar, W., Laufer, G., Madl, C., Kramer, L., Eisenhuber, E., Simon, P., Kupilik, N., Schreiner, W., Pacher, R., Bunzel, B., Wolner, E., Grimm, G. Circulation (1996) [Pubmed]
  14. High prevalence of spontaneous portal-systemic shunts in persistent hepatic encephalopathy: a case-control study. Riggio, O., Efrati, C., Catalano, C., Pediconi, F., Mecarelli, O., Accornero, N., Nicolao, F., Angeloni, S., Masini, A., Ridola, L., Attili, A.F., Merli, M. Hepatology (2005) [Pubmed]
  15. Clinical efficacy of lactulose in cirrhotic patients with and without subclinical hepatic encephalopathy. Watanabe, A., Sakai, T., Sato, S., Imai, F., Ohto, M., Arakawa, Y., Toda, G., Kobayashi, K., Muto, Y., Tsujii, T., Kawasaki, H., Okita, K., Tanikawa, K., Fujiyama, S., Shimada, S. Hepatology (1997) [Pubmed]
  16. The AIMS2-SF: a short form of the Arthritis Impact Measurement Scales 2. French Quality of Life in Rheumatology Group. Guillemin, F., Coste, J., Pouchot, J., Ghézail, M., Bregeon, C., Sany, J. Arthritis Rheum. (1997) [Pubmed]
  17. Neuroendocrine effects of buspirone in patients with generalized anxiety disorder. Cohn, J.B., Wilcox, C.S., Meltzer, H.Y. Am. J. Med. (1986) [Pubmed]
  18. Initial and steady-state effects of diphenhydramine and loratadine on sedation, cognition, mood, and psychomotor performance. Kay, G.G., Berman, B., Mockoviak, S.H., Morris, C.E., Reeves, D., Starbuck, V., Sukenik, E., Harris, A.G. Arch. Intern. Med. (1997) [Pubmed]
  19. Longitudinal MRI study of hippocampal volume in trauma survivors with PTSD. Bonne, O., Brandes, D., Gilboa, A., Gomori, J.M., Shenton, M.E., Pitman, R.K., Shalev, A.Y. The American journal of psychiatry. (2001) [Pubmed]
  20. Abnormalities of cognitive functions in IDDM revealed by P300 event-related potential analysis. Comparison with short-latency evoked potentials and psychometric tests. Pozzessere, G., Valle, E., de Crignis, S., Cordischi, V.M., Fattapposta, F., Rizzo, P.A., Pietravalle, P., Cristina, G., Morano, S., di Mario, U. Diabetes (1991) [Pubmed]
  21. A naturalistic investigation of the effects of day-long consumption of tea, coffee and water on alertness, sleep onset and sleep quality. Hindmarch, I., Rigney, U., Stanley, N., Quinlan, P., Rycroft, J., Lane, J. Psychopharmacology (Berl.) (2000) [Pubmed]
  22. EEG and auditory evoked potential P300 compared with psychometric tests in assessing vigilance after benzodiazepine sedation and antagonism. Engelhardt, W., Friess, K., Hartung, E., Sold, M., Dierks, T. British journal of anaesthesia. (1992) [Pubmed]
  23. The psychometric and cardiac effects of dimenhydrinate in the hyperbaric environment. Taylor, D.M., O'Toole, K.S., Auble, T.E., Ryan, C.M., Sherman, D.R. Pharmacotherapy (2000) [Pubmed]
  24. Differential cognitive outcomes in the Hypertensive Old People in Edinburgh study. Starr, J.M., Whalley, L.J. J. Neurol. Sci. (2005) [Pubmed]
  25. Cerebral blood flow and glucose metabolism in hypothyroidism: a positron emission tomography study. Constant, E.L., de Volder, A.G., Ivanoiu, A., Bol, A., Labar, D., Seghers, A., Cosnard, G., Melin, J., Daumerie, C. J. Clin. Endocrinol. Metab. (2001) [Pubmed]
  26. Idiopathic normal pressure hydrocephalus: the CSF tap-test may predict the clinical response to shunting. Sand, T., Bovim, G., Grimse, R., Myhr, G., Helde, G., Cappelen, J. Acta neurologica Scandinavica. (1994) [Pubmed]
  27. Otoneurological findings in workers exposed to styrene. Möller, C., Odkvist, L., Larsby, B., Tham, R., Ledin, T., Bergholtz, L. Scandinavian journal of work, environment & health. (1990) [Pubmed]
  28. Results of computerized tomography, psychometric testing and dietary studies in social drinkers, with emphasis on reversibility after abstinence. Cala, L.A., Jones, B., Burns, P., Davis, R.E., Stenhouse, N., Mastaglia, F.L. Med. J. Aust. (1983) [Pubmed]
  29. Evaluation of encephalotropic and psychotropic properties of gabapentin in man by pharmaco-EEG and psychometry. Saletu, B., Grünberger, J., Linzmayer, L. International journal of clinical pharmacology, therapy, and toxicology. (1986) [Pubmed]
  30. Long-lasting effects of (+/-)3,4-methylenedioxymethamphetamine (ecstasy) on serotonin system function in humans. Gerra, G., Zaimovic, A., Ferri, M., Zambelli, U., Timpano, M., Neri, E., Marzocchi, G.F., Delsignore, R., Brambilla, F. Biol. Psychiatry (2000) [Pubmed]
  31. Effects of (+/-) 3,4-methylene-dioxymethamphetamine (ecstasy) on dopamine system function in humans. Gerra, G., Zaimovic, A., Moi, G., Giusti, F., Gardini, S., Delsignore, R., Laviola, G., Macchia, T., Brambilla, F. Behav. Brain Res. (2002) [Pubmed]
  32. Differences in cerebrospinal fluid dynamics do not affect the levels of biochemical markers in ventricular CSF from patients with aqueductal stenosis and idiopathic normal pressure hydrocephalus. Tisell, M., Tullberg, M., Månsson, J.E., Fredman, P., Blennow, K., Wikkelsø, C. Eur. J. Neurol. (2004) [Pubmed]
  33. Endogenous opioid tone in patients with rheumatoid arthritis. Kassimos, D., Choy, E.H., Grossman, A.B., Chikanza, I.C., Panayi, G.S. Br. J. Rheumatol. (1996) [Pubmed]
  34. Growth hormone and thyrotropin hormone secretion in Alzheimer's disease. Gomez, J.M., Aguilar, M., Soler, J. The journal of nutrition, health & aging. (2000) [Pubmed]
  35. Permutation methods for the structured exploratory data analysis (SEDA) of familial trait values. Karlin, S., Williams, P.T. Am. J. Hum. Genet. (1984) [Pubmed]
  36. Rates of progression in mild cognitive impairment and early Alzheimer's disease. Storandt, M., Grant, E.A., Miller, J.P., Morris, J.C. Neurology (2002) [Pubmed]
  37. Regional cerebral blood flow in patients with mild hypothyroidism. Krausz, Y., Freedman, N., Lester, H., Newman, J.P., Barkai, G., Bocher, M., Chisin, R., Bonne, O. J. Nucl. Med. (2004) [Pubmed]
  38. Acute psychological effects of 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") are attenuated by the serotonin uptake inhibitor citalopram. Liechti, M.E., Baumann, C., Gamma, A., Vollenweider, F.X. Neuropsychopharmacology (2000) [Pubmed]
  39. Validity and reliability of an Italian version of the revised Leeds disability questionnaire for patients with ankylosing spondylitis. Lubrano, E., Puttini, P.S., Parsons, W.J., D'Angelo, S., Cimmino, M.A., Serino, F., Pappone, N. Rheumatology (Oxford, England) (2005) [Pubmed]
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