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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

trans-activation of RNA polymerase II and III promoters by SV40 small t antigen.

A biochemical role for SV40 small t antigen (t) in the viral infectious cycle that would explain the strong conservation of t structure among papovaviruses and its role as a helper of SV40 large T antigen function in the viral transforming process is not understood. Here, we report an intracellular biochemical function of the protein--the capacity to trans-activate selected RNA polymerase II and III-requiring promoters. Since t has failed in the past to bind to DNA and did not stimulate all polymerase II-requiring promoters tested, it likely trans-activates, at least in part, by modifying the activity of selected transcription factors.[1]


  1. trans-activation of RNA polymerase II and III promoters by SV40 small t antigen. Loeken, M., Bikel, I., Livingston, D.M., Brady, J. Cell (1988) [Pubmed]
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