Gene Review:
SV40gp6 - large T antigen
Simian virus 40
- SV40 gene expression is modulated by the cooperative binding of T antigen to DNA. Myers, R.M., Rio, D.C., Robbins, A.K., Tjian, R. Cell (1981)
- Intestinal dysplasia induced by simian virus 40 T antigen is independent of p53. Markovics, J.A., Carroll, P.A., Robles, M.T., Pope, H., Coopersmith, C.M., Pipas, J.M. J. Virol. (2005)
- Simian virus 40 large T-antigen, but not small T-antigen, trans-activates the human cytomegalovirus major immediate early promoter. Moens, U., Van Ghelue, M., Kristoffersen, A.K., Johansen, B., Rekvig, O.P., Degré, M., Rollag, H. Virus Genes (2001)
- Role of the amino-terminal domain of simian virus 40 early region in inducing tumors in secretin-expressing cells in transgenic mice. Ratineau, C., Ronco, A., Leiter, A.B. Gastroenterology (2000)
- Requirement for the simian virus 40 small tumor antigen in tumorigenesis in transgenic mice. Choi, Y.W., Lee, I.C., Ross, S.R. Mol. Cell. Biol. (1988)
- Cytosolic proteins that specifically bind nuclear location signals are receptors for nuclear import. Adam, S.A., Gerace, L. Cell (1991)
- Region-specific differentiation of the hippocampal stem cell line HiB5 upon implantation into the developing mammalian brain. Renfranz, P.J., Cunningham, M.G., McKay, R.D. Cell (1991)
- SV40 large T antigen binds preferentially to an underphosphorylated member of the retinoblastoma susceptibility gene product family. Ludlow, J.W., DeCaprio, J.A., Huang, C.M., Lee, W.H., Paucha, E., Livingston, D.M. Cell (1989)
- The mouse type IV c-abl gene product is a nuclear protein, and activation of transforming ability is associated with cytoplasmic localization. Van Etten, R.A., Jackson, P., Baltimore, D. Cell (1989)
- trans-activation of RNA polymerase II and III promoters by SV40 small t antigen. Loeken, M., Bikel, I., Livingston, D.M., Brady, J. Cell (1988)
- Immortalization of osteoclast precursors by targeting Bcl -XL and Simian virus 40 large T antigen to the osteoclast lineage in transgenic mice. Hentunen, T.A., Reddy, S.V., Boyce, B.F., Devlin, R., Park, H.R., Chung, H., Selander, K.S., Dallas, M., Kurihara, N., Galson, D.L., Goldring, S.R., Koop, B.A., Windle, J.J., Roodman, G.D. J. Clin. Invest. (1998)
- Bilateral retinal and brain tumors in transgenic mice expressing simian virus 40 large T antigen under control of the human interphotoreceptor retinoid-binding protein promoter. al-Ubaidi, M.R., Font, R.L., Quiambao, A.B., Keener, M.J., Liou, G.I., Overbeek, P.A., Baehr, W. J. Cell Biol. (1992)
- Sequence and functional analysis of the positively acting regulatory gene amdR from Aspergillus nidulans. Andrianopoulos, A., Hynes, M.J. Mol. Cell. Biol. (1990)
- The B-domain lysine patch of pRB is required for binding to large T antigen and release of E2F by phosphorylation. Brown, V.D., Gallie, B.L. Mol. Cell. Biol. (2002)
- Association of simian virus 40 T antigen with the nuclear matrix of infected and transformed monkey cells. Covey, L., Choi, Y., Prives, C. Mol. Cell. Biol. (1984)
- Modification of SV40 T antigen by poly ADP-ribosylation. Goldman, N., Brown, M., Khoury, G. Cell (1981)
- Essential contact residues within SV40 large T antigen binding sites I and II identified by alkylation-interference. Jones, K.A., Tjian, R. Cell (1984)
- Inhibition of lens fiber cell morphogenesis by expression of a mutant SV40 large T antigen that binds CREB-binding protein/p300 but not pRb. Chen, Q., Liang, D., Fromm, L.D., Overbeek, P.A. J. Biol. Chem. (2004)
- Structural basis for the cooperative assembly of large T antigen on the origin of replication. Valle, M., Chen, X.S., Donate, L.E., Fanning, E., Carazo, J.M. J. Mol. Biol. (2006)
- Conditional immortalization of normal and dysgenic mouse muscle cells by the SV40 large T antigen under the vimentin promoter control. Pinçon-Raymond, M., Vicart, P., Bois, P., Chassande, O., Romey, G., Varadi, G., Li, Z.L., Lazdunski, M., Rieger, F., Paulin, D. Dev. Biol. (1991)
- Cell adhesion markers are expressed by a stable human endothelial cell line transformed by the SV40 large T antigen under vimentin promoter control. Vicart, P., Testut, P., Schwartz, B., Llorens-Cortes, C., Perdomo, J.J., Paulin, D. J. Cell. Physiol. (1993)
- The SV40 small t antigen is essential for the morphological transformation of human fibroblasts. de Ronde, A., Sol, C.J., van Strien, A., ter Schegget, J., van der Noordaa, J. Virology (1989)
- Characterization of a new simian virus 40 mutant, tsA3900, isolated from deletion mutant tsA1499. Hutchinson, N.I., Chang, L.S., Pater, M.M., Bouck, N., Shenk, T.E., di Mayorca, G. J. Virol. (1985)
- Selection for precise chromosomal targeting of a dominant marker by homologous recombination. Dorin, J.R., Inglis, J.D., Porteous, D.J. Science (1989)
- Crystal structure of SV40 large T-antigen bound to p53: interplay between a viral oncoprotein and a cellular tumor suppressor. Lilyestrom, W., Klein, M.G., Zhang, R., Joachimiak, A., Chen, X.S. Genes Dev. (2006)
- Molecular characterization of a karyophilic, histone-binding protein: cDNA cloning, amino acid sequence and expression of nuclear protein N1/N2 of Xenopus laevis. Kleinschmidt, J.A., Dingwall, C., Maier, G., Franke, W.W. EMBO J. (1986)
- Methylation-induced G(2)/M arrest requires a full complement of the mismatch repair protein hMLH1. Cejka, P., Stojic, L., Mojas, N., Russell, A.M., Heinimann, K., Cannavó, E., di Pietro, M., Marra, G., Jiricny, J. EMBO J. (2003)
- SV40 small t antigen enhances the transformation activity of limiting concentrations of SV40 large T antigen. Bikel, I., Montano, X., Agha, M.E., Brown, M., McCormack, M., Boltax, J., Livingston, D.M. Cell (1987)
- SV40 infection induces telomerase activity in human mesothelial cells. Foddis, R., De Rienzo, A., Broccoli, D., Bocchetta, M., Stekala, E., Rizzo, P., Tosolini, A., Grobelny, J.V., Jhanwar, S.C., Pass, H.I., Testa, J.R., Carbone, M. Oncogene (2002)
- Relationship of oligomerization to enzymatic and DNA-binding properties of the SV40 large T antigen. Bradley, M.K., Griffin, J.D., Livingston, D.M. Cell (1982)
- An embryo protein induced by SV40 virus transformation of mouse cells. Mora, P.T., Chandrasekaran, K., McFarland, V.W. Nature (1980)
- The release of growth arrest by microinjection of adenovirus E1A DNA. Stabel, S., Argos, P., Philipson, L. EMBO J. (1985)