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Gene Review

SV40gp7  -  small t antigen

Simian virus 40

 
 
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Disease relevance of SV40gp7

 

High impact information on SV40gp7

  • Depleting Menin immortalizes primary human fibroblasts and causes a transformation phenotype when coupled with expression of SV40 Large and Small T antigen and oncogenic ras [6].
  • A biochemical role for SV40 small t antigen (t) in the viral infectious cycle that would explain the strong conservation of t structure among papovaviruses and its role as a helper of SV40 large T antigen function in the viral transforming process is not understood [7].
  • METHODS: Two SV40 early-region transgenes containing a deletion that eliminated expression of the small t antigen were expressed in transgenic mice under control of the secretin gene [5].
  • The SV40 small T-antigen, which is similar to PyST in containing a J domain and in binding to the PP2A AC dimer, does not activate the MAP kinase cascade, but does stimulate phosphorylation of AKT in a PP2A-dependent manner [8].
  • Interestingly, the polyoma small T-antigen (PyST), which shares with MTA both partial amino acid sequence homology and cellular location, also activates the MAP kinase cascade [8].
 

Chemical compound and disease context of SV40gp7

 

Biological context of SV40gp7

 

Anatomical context of SV40gp7

 

Associations of SV40gp7 with chemical compounds

  • The small-t-antigen-induced increase in Akt and PKC lambda activities was not inhibited by wortmannin, while the ability of small t antigen to enhance glucose transport was inhibited by dominant negative Akt (DN-Akt) expression and Akt small interfering RNA (siRNA) but not by DN-PKC lambda expression or PKC lambda siRNA [21].
  • Furthermore, Shc tyrosine phosphorylation and its association with Grb2 were also elevated in small-t-antigen-expressing cells [22].
  • Elevated levels of cyclic AMP are not involved in growth arrest of CV-1 cells by methylxanthines, and small-t antigen does not alter cyclic AMP levels dramatically after infection [13].
  • In the presence of N-ethylmaleimide, the 37-kDA protein was selectively released from immune complexes, leaving the small-t antigen and 61-kDa protein in association [23].
  • As observed with 10 nM OA, both phospho-ser15-p53 levels and p53 activity were increased by 10 microM fostriecin or SV40 small t-antigen [24].
 

Regulatory relationships of SV40gp7

 

Analytical, diagnostic and therapeutic context of SV40gp7

References

  1. Control of protein phosphatase 2A by simian virus 40 small-t antigen. Yang, S.I., Lickteig, R.L., Estes, R., Rundell, K., Walter, G., Mumby, M.C. Mol. Cell. Biol. (1991) [Pubmed]
  2. The SV40 small t-antigen prevents mammary gland differentiation and induces breast cancer formation in transgenic mice; truncated large T-antigen molecules harboring the intact p53 and pRb binding region do not have this effect. Goetz, F., Tzeng, Y.J., Guhl, E., Merker, J., Graessmann, M., Graessmann, A. Oncogene (2001) [Pubmed]
  3. Simian virus 40 large T-antigen, but not small T-antigen, trans-activates the human cytomegalovirus major immediate early promoter. Moens, U., Van Ghelue, M., Kristoffersen, A.K., Johansen, B., Rekvig, O.P., Degré, M., Rollag, H. Virus Genes (2001) [Pubmed]
  4. SV40 small t antigen enhances the transformation activity of limiting concentrations of SV40 large T antigen. Bikel, I., Montano, X., Agha, M.E., Brown, M., McCormack, M., Boltax, J., Livingston, D.M. Cell (1987) [Pubmed]
  5. Role of the amino-terminal domain of simian virus 40 early region in inducing tumors in secretin-expressing cells in transgenic mice. Ratineau, C., Ronco, A., Leiter, A.B. Gastroenterology (2000) [Pubmed]
  6. Multiple tumor suppressor pathways negatively regulate telomerase. Lin, S.Y., Elledge, S.J. Cell (2003) [Pubmed]
  7. trans-activation of RNA polymerase II and III promoters by SV40 small t antigen. Loeken, M., Bikel, I., Livingston, D.M., Brady, J. Cell (1988) [Pubmed]
  8. Polyoma and SV40 proteins differentially regulate PP2A to activate distinct cellular signaling pathways involved in growth control. Rodriguez-Viciana, P., Collins, C., Fried, M. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  9. Isolation and characterization of NIH 3T3 cells expressing polyomavirus small T antigen. Noda, T., Satake, M., Robins, T., Ito, Y. J. Virol. (1986) [Pubmed]
  10. Nuclear transport of proteins translated in vitro from SP6 plasmid-generated mRNAs. Parnaik, V.K., Kennady, P.K. Mol. Cell. Biol. (1990) [Pubmed]
  11. Reversal of simian virus 40 small-t-antigen-induced theophylline resistance. Rundell, K., Calenoff, M., Renz, C. J. Virol. (1984) [Pubmed]
  12. Effect of zinc ions on the biochemical behavior of simian virus 40 small-t antigen expressed in bacteria. Goswami, R., Turk, B., Enderle, K., Howe, A., Rundell, K. J. Virol. (1992) [Pubmed]
  13. Simian virus 40 small-t antigen-induced theophylline resistance is not mediated by cyclic AMP. Renz, C., Rundell, K. J. Virol. (1985) [Pubmed]
  14. Inhibition of lens fiber cell morphogenesis by expression of a mutant SV40 large T antigen that binds CREB-binding protein/p300 but not pRb. Chen, Q., Liang, D., Fromm, L.D., Overbeek, P.A. J. Biol. Chem. (2004) [Pubmed]
  15. Nucleotide sequence analysis of viable deletion mutants lacking segments of the simian virus 40 genome coding for small t antigen. Thimmappaya, B., Shenk, T. J. Virol. (1979) [Pubmed]
  16. Nucleotide sequence deletions within the coding region for small-t antigen of simian virus 40. Volckaert, G., Feunteun, J., Crawford, L.V., Berg, P., Fiers, W. J. Virol. (1979) [Pubmed]
  17. Cell adhesion markers are expressed by a stable human endothelial cell line transformed by the SV40 large T antigen under vimentin promoter control. Vicart, P., Testut, P., Schwartz, B., Llorens-Cortes, C., Perdomo, J.J., Paulin, D. J. Cell. Physiol. (1993) [Pubmed]
  18. Conditional immortalization of normal and dysgenic mouse muscle cells by the SV40 large T antigen under the vimentin promoter control. Pinçon-Raymond, M., Vicart, P., Bois, P., Chassande, O., Romey, G., Varadi, G., Li, Z.L., Lazdunski, M., Rieger, F., Paulin, D. Dev. Biol. (1991) [Pubmed]
  19. The SV40 small t antigen is essential for the morphological transformation of human fibroblasts. de Ronde, A., Sol, C.J., van Strien, A., ter Schegget, J., van der Noordaa, J. Virology (1989) [Pubmed]
  20. Recombinant retroviruses that transduce individual polyoma tumor antigens: effects on growth and differentiation. Cherington, V., Morgan, B., Spiegelman, B.M., Roberts, T.M. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  21. Protein phosphatase 2A negatively regulates insulin's metabolic signaling pathway by inhibiting Akt (protein kinase B) activity in 3T3-L1 adipocytes. Ugi, S., Imamura, T., Maegawa, H., Egawa, K., Yoshizaki, T., Shi, K., Obata, T., Ebina, Y., Kashiwagi, A., Olefsky, J.M. Mol. Cell. Biol. (2004) [Pubmed]
  22. Protein phosphatase 2A forms a molecular complex with Shc and regulates Shc tyrosine phosphorylation and downstream mitogenic signaling. Ugi, S., Imamura, T., Ricketts, W., Olefsky, J.M. Mol. Cell. Biol. (2002) [Pubmed]
  23. Association of simian virus 40 small-t antigen with the 61-kilodalton component of a cellular protein complex. Joshi, B., Rundell, K. J. Virol. (1990) [Pubmed]
  24. Inhibition of PP2A, but not PP5, mediates p53 activation by low levels of okadaic acid in rat liver epithelial cells. Messner, D.J., Romeo, C., Boynton, A., Rossie, S. J. Cell. Biochem. (2006) [Pubmed]
  25. The T/t common region of simian virus 40 large T antigen contains a distinct transformation-governing sequence. Marsilio, E., Cheng, S.H., Schaffhausen, B., Paucha, E., Livingston, D.M. J. Virol. (1991) [Pubmed]
  26. Development, progression, and androgen-dependence of prostate tumors in probasin-large T antigen transgenic mice: a model for prostate cancer. Kasper, S., Sheppard, P.C., Yan, Y., Pettigrew, N., Borowsky, A.D., Prins, G.S., Dodd, J.G., Duckworth, M.L., Matusik, R.J. Lab. Invest. (1998) [Pubmed]
  27. The detection of simian virus 40 in human tumors by polymerase chain reaction. Rizzo, P., Di Resta, I., Powers, A., Matker, C.M., Zhang, A., Mutti, L., Kast, W.M., Pass, H., Carbone, M. Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace / Fondazione clinica del lavoro, IRCCS [and] Istituto di clinica tisiologica e malattie apparato respiratorio, Università di Napoli, Secondo ateneo. (1998) [Pubmed]
  28. A novel in vivo transcription assay demonstrates the presence of globin-inducing trans-acting factors in uninduced murine erythroleukemia cells. Wrighton, N., Grosveld, F. Mol. Cell. Biol. (1988) [Pubmed]
 
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