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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Augmented interleukin-1 production and HLA-DR expression in the synovium of rheumatoid arthritis patients. Possible involvement in joint destruction.

Potent interleukin-1 ( IL-1) activity was detected in culture supernatants from synovium, obtained by arthroscopy, from rheumatoid arthritis ( RA) patients but not from non- RA patients. Production of IL-1 by RA synovium correlated well with findings of inflammation on arthroscopy and HLA-DR expression in immunohistochemical staining. Furthermore, there was a positive correlation between IL-1 production from RA synovium and joint changes detected on roentgenograms. These findings strongly suggest that IL-1 might play an important role in the joint destruction in RA.[1]

References

  1. Augmented interleukin-1 production and HLA-DR expression in the synovium of rheumatoid arthritis patients. Possible involvement in joint destruction. Miyasaka, N., Sato, K., Goto, M., Sasano, M., Natsuyama, M., Inoue, K., Nishioka, K. Arthritis Rheum. (1988) [Pubmed]
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