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MeSH Review

Synovial Membrane

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Disease relevance of Synovial Membrane


High impact information on Synovial Membrane

  • Rheumatoid arthritis (RA), a systemic disease, is characterized by a chronic inflammatory reaction in the synovium of joints and is associated with degeneration of cartilage and erosion of juxta-articular bone [6].
  • These studies emphasize in importance of control of activation in regulation collagenase activity, It is likely that rheumatoid synovium produces both latent collagenase and plasminogen activator; plasmin is activated from its zymogen, plasminogen, present in inflamed tissues, and in turn activates collagenase [7].
  • XBP-1 transcripts were rapidly upregulated in vitro by stimuli that induce plasma-cell differentiation, and were found at high levels in plasma cells from rheumatoid synovium [8].
  • CD44 is overexpressed by synovial cells and leukocytes, and hyaluronan is overproduced in the rheumatoid synovium and in other inflammatory sites [9].
  • Synoviolin/Hrd1 was highly expressed in the rheumatoid synovium, and mice overexpressing this enzyme developed spontaneous arthropathy [10].

Chemical compound and disease context of Synovial Membrane


Biological context of Synovial Membrane


Anatomical context of Synovial Membrane


Associations of Synovial Membrane with chemical compounds

  • Inhibition was observed with concentrations as low as 1 microgram/ml GST, 5 micrograms/ml gold chloride, and 0.1 microgram/ml auranofin, levels attainable in blood and synovium of patients [25].
  • Homing of mucosal leukocytes to joints. Distinct endothelial ligands in synovium mediate leukocyte-subtype specific adhesion [26].
  • Thymus-dependent and -independent regulation of Ia antigen expression in situ by cells in the synovium of rats with streptococcal cell wall-induced arthritis. Differences in site and intensity of expression in euthymic, athymic, and cyclosporin A-treated LEW and F344 rats [27].
  • It shows promise in biological (clinical) specimens also, as demonstrated here in studies of synovial fluid, synovium, and gouty tophus, selected for their known content of sodium urate and calcium pyrophosphate crystals [28].
  • We hypothesise that deferiprone-induced shifts of iron to synovium resulted in tissue damage, accelerated by free-radical formation during incomplete complexation of iron and this bidentate chelator [29].

Gene context of Synovial Membrane


Analytical, diagnostic and therapeutic context of Synovial Membrane


  1. Two monoclonal antibodies generated against human hsp60 show reactivity with synovial membranes of patients with juvenile chronic arthritis. Boog, C.J., de Graeff-Meeder, E.R., Lucassen, M.A., van der Zee, R., Voorhorst-Ogink, M.M., van Kooten, P.J., Geuze, H.J., van Eden, W. J. Exp. Med. (1992) [Pubmed]
  2. Activation pathways of synovial T lymphocytes. Expression and function of the UM4D4/CDw60 antigen. Fox, D.A., Millard, J.A., Kan, L., Zeldes, W.S., Davis, W., Higgs, J., Emmrich, F., Kinne, R.W. J. Clin. Invest. (1990) [Pubmed]
  3. Transforming growth factor beta 1 suppresses acute and chronic arthritis in experimental animals. Brandes, M.E., Allen, J.B., Ogawa, Y., Wahl, S.M. J. Clin. Invest. (1991) [Pubmed]
  4. Human parvovirus B19 as a causative agent for rheumatoid arthritis. Takahashi, Y., Murai, C., Shibata, S., Munakata, Y., Ishii, T., Ishii, K., Saitoh, T., Sawai, T., Sugamura, K., Sasaki, T. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  5. Persistence of collagen type II-specific T-cell clones in the synovial membrane of a patient with rheumatoid arthritis. Londei, M., Savill, C.M., Verhoef, A., Brennan, F., Leech, Z.A., Duance, V., Maini, R.N., Feldmann, M. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  6. Anti-TNF alpha therapy of rheumatoid arthritis: what have we learned? Feldmann, M., Maini, R.N. Annu. Rev. Immunol. (2001) [Pubmed]
  7. Endogenous activiation of latent collagenase by rheumatoid synovial cells. Evidence for a role of plasminogen activator. Werb, Z., Mainardi, C.L., Vater, C.A., Harris, E.D. N. Engl. J. Med. (1977) [Pubmed]
  8. Plasma cell differentiation requires the transcription factor XBP-1. Reimold, A.M., Iwakoshi, N.N., Manis, J., Vallabhajosyula, P., Szomolanyi-Tsuda, E., Gravallese, E.M., Friend, D., Grusby, M.J., Alt, F., Glimcher, L.H. Nature (2001) [Pubmed]
  9. Anti-CD44 treatment abrogates tissue oedema and leukocyte infiltration in murine arthritis. Mikecz, K., Brennan, F.R., Kim, J.H., Glant, T.T. Nat. Med. (1995) [Pubmed]
  10. Synoviolin/Hrd1, an E3 ubiquitin ligase, as a novel pathogenic factor for arthropathy. Amano, T., Yamasaki, S., Yagishita, N., Tsuchimochi, K., Shin, H., Kawahara, K., Aratani, S., Fujita, H., Zhang, L., Ikeda, R., Fujii, R., Miura, N., Komiya, S., Nishioka, K., Maruyama, I., Fukamizu, A., Nakajima, T. Genes Dev. (2003) [Pubmed]
  11. Elevated levels of collagenase and prostaglandin E2 from synovium associated with erosion of cartilage and bone in a patient with chronic Lyme arthritis. Steere, A.C., Brinckerhoff, C.E., Miller, D.J., Drinker, H., Harris, E.D., Malawista, S.E. Arthritis Rheum. (1980) [Pubmed]
  12. Synovial distribution of alpha d/CD18, a novel leukointegrin. Comparison with other integrins and their ligands. el-Gabalawy, H., Canvin, J., Ma, G.M., Van der Vieren, M., Hoffman, P., Gallatin, M., Wilkins, J. Arthritis Rheum. (1996) [Pubmed]
  13. Differential expression of cathepsins B and L compared with matrix metalloproteinases and their respective inhibitors in rheumatoid arthritis and osteoarthritis: a parallel investigation by semiquantitative reverse transcriptase-polymerase chain reaction and immunohistochemistry. Keyszer, G., Redlich, A., Häupl, T., Zacher, J., Sparmann, M., Engethüm, U., Gay, S., Burmester, G.R. Arthritis Rheum. (1998) [Pubmed]
  14. Effects of low-dose, noncytotoxic, intraarticular liposomal clodronate on development of erosions and proteoglycan loss in established antigen-induced arthritis in rabbits. Ceponis, A., Waris, E., Mönkkönen, J., Laasonen, L., Hyttinen, M., Solovieva, S.A., Hanemaaijer, R., Bitsch, A., Konttinen, Y.T. Arthritis Rheum. (2001) [Pubmed]
  15. Intracellular free radical production in synovial T lymphocytes from patients with rheumatoid arthritis. Remans, P.H., van Oosterhout, M., Smeets, T.J., Sanders, M., Frederiks, W.M., Reedquist, K.A., Tak, P.P., Breedveld, F.C., van Laar, J.M. Arthritis Rheum. (2005) [Pubmed]
  16. Apoptosis in rheumatoid arthritis synovium. Firestein, G.S., Yeo, M., Zvaifler, N.J. J. Clin. Invest. (1995) [Pubmed]
  17. Transin/stromelysin expression in the synovium of rats with experimental erosive arthritis. In situ localization and kinetics of expression of the transformation-associated metalloproteinase in euthymic and athymic Lewis rats. Case, J.P., Sano, H., Lafyatis, R., Remmers, E.F., Kumkumian, G.K., Wilder, R.L. J. Clin. Invest. (1989) [Pubmed]
  18. Somatic mutation and CDR3 lengths of immunoglobulin kappa light chains expressed in patients with rheumatoid arthritis and in normal individuals. Bridges, S.L., Lee, S.K., Johnson, M.L., Lavelle, J.C., Fowler, P.G., Koopman, W.J., Schroeder, H.W. J. Clin. Invest. (1995) [Pubmed]
  19. Somatic mutations in the p53 tumor suppressor gene in rheumatoid arthritis synovium. Firestein, G.S., Echeverri, F., Yeo, M., Zvaifler, N.J., Green, D.R. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  20. Reduction of synovial sublining layer inflammation and proinflammatory cytokine expression in psoriatic arthritis treated with methotrexate. Kane, D., Gogarty, M., O'leary, J., Silva, I., Bermingham, N., Bresnihan, B., Fitzgerald, O. Arthritis Rheum. (2004) [Pubmed]
  21. The role of interleukin-15 in T-cell migration and activation in rheumatoid arthritis. McInnes, I.B., al-Mughales, J., Field, M., Leung, B.P., Huang, F.P., Dixon, R., Sturrock, R.D., Wilkinson, P.C., Liew, F.Y. Nat. Med. (1996) [Pubmed]
  22. Human synovium releases a factor which stimulates chondrocyte production of PGE and plasminogen activator. Meats, J.E., McGuire, M.B., Russell, R.G. Nature (1980) [Pubmed]
  23. Genetic analysis of self-associating immunoglobulin G rheumatoid factors from two rheumatoid synovia implicates an antigen-driven response. Olee, T., Lu, E.W., Huang, D.F., Soto-Gil, R.W., Deftos, M., Kozin, F., Carson, D.A., Chen, P.P. J. Exp. Med. (1992) [Pubmed]
  24. Prolylcarboxypeptidase (angiotensinase C) in human lung and cultured cells. Kumamoto, K., Stewart, T.A., Johnson, A.R., Erdös, E.G. J. Clin. Invest. (1981) [Pubmed]
  25. Inhibition of human endothelial cell proliferation by gold compounds. Matsubara, T., Ziff, M. J. Clin. Invest. (1987) [Pubmed]
  26. Homing of mucosal leukocytes to joints. Distinct endothelial ligands in synovium mediate leukocyte-subtype specific adhesion. Salmi, M., Rajala, P., Jalkanen, S. J. Clin. Invest. (1997) [Pubmed]
  27. Thymus-dependent and -independent regulation of Ia antigen expression in situ by cells in the synovium of rats with streptococcal cell wall-induced arthritis. Differences in site and intensity of expression in euthymic, athymic, and cyclosporin A-treated LEW and F344 rats. Wilder, R.L., Allen, J.B., Hansen, C. J. Clin. Invest. (1987) [Pubmed]
  28. Identification of pathological mineral deposits by Raman microscopy. McGill, N., Dieppe, P.A., Bowden, M., Gardiner, D.J., Hall, M. Lancet (1991) [Pubmed]
  29. Arthropathy in thalassaemia patients receiving deferiprone. Berkovitch, M., Laxer, R.M., Inman, R., Koren, G., Pritzker, K.P., Fritzler, M.J., Olivieri, N.F. Lancet (1994) [Pubmed]
  30. Inflammatory microcrystals differentially regulate the secretion of macrophage inflammatory protein 1 and interleukin 8 by human neutrophils: a possible mechanism of neutrophil recruitment to sites of inflammation in synovitis. Hachicha, M., Naccache, P.H., McColl, S.R. J. Exp. Med. (1995) [Pubmed]
  31. Immunoregulatory role of interleukin 10 in rheumatoid arthritis. Katsikis, P.D., Chu, C.Q., Brennan, F.M., Maini, R.N., Feldmann, M. J. Exp. Med. (1994) [Pubmed]
  32. Enhanced production of monocyte chemoattractant protein-1 in rheumatoid arthritis. Koch, A.E., Kunkel, S.L., Harlow, L.A., Johnson, B., Evanoff, H.L., Haines, G.K., Burdick, M.D., Pope, R.M., Strieter, R.M. J. Clin. Invest. (1992) [Pubmed]
  33. Paradoxical effects of a synthetic metalloproteinase inhibitor that blocks both p55 and p75 TNF receptor shedding and TNF alpha processing in RA synovial membrane cell cultures. Williams, L.M., Gibbons, D.L., Gearing, A., Maini, R.N., Feldmann, M., Brennan, F.M. J. Clin. Invest. (1996) [Pubmed]
  34. c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis. Han, Z., Boyle, D.L., Chang, L., Bennett, B., Karin, M., Yang, L., Manning, A.M., Firestein, G.S. J. Clin. Invest. (2001) [Pubmed]
  35. Nitric oxide production and inducible nitric oxide synthase expression in inflammatory arthritides. Sakurai, H., Kohsaka, H., Liu, M.F., Higashiyama, H., Hirata, Y., Kanno, K., Saito, I., Miyasaka, N. J. Clin. Invest. (1995) [Pubmed]
  36. Rheumatoid arthritis synovial membrane contains a 62,000-molecular-weight protein that shares an antigenic epitope with the Epstein-Barr virus-encoded associated nuclear antigen. Fox, R., Sportsman, R., Rhodes, G., Luka, J., Pearson, G., Vaughan, J. J. Clin. Invest. (1986) [Pubmed]
  37. Differential expression pattern of membrane-type matrix metalloproteinases in rheumatoid arthritis. Pap, T., Shigeyama, Y., Kuchen, S., Fernihough, J.K., Simmen, B., Gay, R.E., Billingham, M., Gay, S. Arthritis Rheum. (2000) [Pubmed]
  38. Suppressed severity of collagen-induced arthritis by in vivo transfection of nuclear factor kappaB decoy oligodeoxynucleotides as a gene therapy. Tomita, T., Takeuchi, E., Tomita, N., Morishita, R., Kaneko, M., Yamamoto, K., Nakase, T., Seki, H., Kato, K., Kaneda, Y., Ochi, T. Arthritis Rheum. (1999) [Pubmed]
  39. Differential in vivo expression of collagenase messenger RNA in synovium and cartilage. Quantitative comparison with stromelysin messenger RNA levels in human rheumatoid arthritis and osteoarthritis patients and in two animal models of acute inflammatory arthritis. Wolfe, G.C., MacNaul, K.L., Buechel, F.F., McDonnell, J., Hoerrner, L.A., Lark, M.W., Moore, V.L., Hutchinson, N.I. Arthritis Rheum. (1993) [Pubmed]
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