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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Intraventricular carbachol mimics the effects of light on the circadian rhythm in the rat pineal gland.

Environmental lighting regulates numerous circadian rhythms, including the cycle in pineal serotonin N-acetyltransferase activity. Brief exposure of rats to light can shift the phase of this enzyme's circadian rhythm. Light also rapidly reduces nocturnal enzyme activity. Intraventricular injections of carbachol, a cholinergic agonist, can mimic both of these effects. Light and carbachol presumably act on the suprachiasmatic nucleus of the hypothalamus. These experiments demonstrate the feasibility of using a neuropharmacologic approach to the mechanisms underlying mammalian circadian rhythms.[1]

References

  1. Intraventricular carbachol mimics the effects of light on the circadian rhythm in the rat pineal gland. Zatz, M., Brownstein, M.J. Science (1979) [Pubmed]
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