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Gene Review

Aanat  -  aralkylamine N-acetyltransferase

Rattus norvegicus

Synonyms: AA-NAT, Aralkylamine N-acetyltransferase, Nat4, Serotonin N-acetyltransferase, Serotonin acetylase, ...
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Disease relevance of Aanat


Psychiatry related information on Aanat


High impact information on Aanat


Biological context of Aanat


Anatomical context of Aanat


Associations of Aanat with chemical compounds

  • To date, our understanding of the oscillatory mechanism of melatonin has been limited to autoregulatory transcriptional and posttranslational regulations of AANAT mRNA [11].
  • In comparison, SB202474, the inactive analog, had no effect on NE or (Bu)(2)cAMP-stimulated AA-NAT activity or protein level [18].
  • Cotreatment with SB202190, a selective p38(MAPK) inhibitor, although having no effect on AA-NAT activity or protein level 3 h after NE treatment, caused a sustained increase in AA-NAT activity and protein level after 6 h of NE treatment [18].
  • Similar results were obtained when AA-NAT was induced by (Bu)(2)cAMP or when SB203580 was used to inhibit p38(MAPK) [18].
  • Serine/threonine phosphatase inhibitors decrease adrenergic arylalkylamine n-acetyltransferase induction in the rat pineal gland [19].
  • Consistent with the enhancing role of hnRNP Q in AANAT IRES activities, knockdown of the hnRNP Q level elicited a dramatic decrease of peak amplitude in the AANAT protein profile parallel to reduced melatonin production in pinealocytes [20].

Regulatory relationships of Aanat


Other interactions of Aanat


Analytical, diagnostic and therapeutic context of Aanat


  1. Serotoninergic system in hamster skin. Slominski, A., Pisarchik, A., Semak, I., Sweatman, T., Szczesniewski, A., Wortsman, J. J. Invest. Dermatol. (2002) [Pubmed]
  2. Atypical 24-hour rhythms of serotonin N-acetyltransferase activity in the rat pineal gland. Vollrath, L., Welker, H.A. Chronobiol. Int. (1988) [Pubmed]
  3. Testicular dysfunction in experimental chronic renal insufficiency: a deficiency of nocturnal pineal N-acetyltransferase activity. Holmes, E.W., Hojvat, S.A., Kahn, S.E., Bermes, E.W. British journal of experimental pathology. (1989) [Pubmed]
  4. Effect of maternal deprivation on N-acetyltransferase activity rhythm in blinded rat pups. Katoh, Y., Takeuchi, Y., Yamazaki, K., Takahashi, K. Physiol. Behav. (1998) [Pubmed]
  5. Diurnal variation in mRNA encoding serotonin N-acetyltransferase in pineal gland. Borjigin, J., Wang, M.M., Snyder, S.H. Nature (1995) [Pubmed]
  6. Melatonin production: proteasomal proteolysis in serotonin N-acetyltransferase regulation. Gastel, J.A., Roseboom, P.H., Rinaldi, P.A., Weller, J.L., Klein, D.C. Science (1998) [Pubmed]
  7. Light and agonists alter pineal N-acetyltransferase induction by vasoactive intestinal polypeptide. Yuwiler, A. Science (1983) [Pubmed]
  8. Intraventricular carbachol mimics the effects of light on the circadian rhythm in the rat pineal gland. Zatz, M., Brownstein, M.J. Science (1979) [Pubmed]
  9. Pineal serotonin N-acetyltransferase activity: abrupt decrease in adenosine 3',5'-monophosphate may be signal for "turnoff". Klein, D.C., Buda, M.J., Kapoor, C.L., Krishna, G. Science (1978) [Pubmed]
  10. Intraocular injection of kainic acid does not abolish the circadian rhythm of arylalkylamine N-acetyltransferase mRNA in rat photoreceptors. Sakamoto, K., Liu, C., Kasamatsu, M., Iuvone, P.M., Tosini, G. Mol. Vis. (2006) [Pubmed]
  11. Rhythmic serotonin N-acetyltransferase mRNA degradation is essential for the maintenance of its circadian oscillation. Kim, T.D., Kim, J.S., Kim, J.H., Myung, J., Chae, H.D., Woo, K.C., Jang, S.K., Koh, D.S., Kim, K.T. Mol. Cell. Biol. (2005) [Pubmed]
  12. A differential role of CREB phosphorylation in cAMP-inducible gene expression in the rat pineal. Spessert, R., Rapp, M., Jastrow, H., Karabul, N., Blum, F., Vollrath, L. Brain Res. (2000) [Pubmed]
  13. Dephosphorylation of pCREB by protein serine/threonine phosphatases is involved in inactivation of Aanat gene transcription in rat pineal gland. Koch, M., Mauhin, V., Stehle, J.H., Schomerus, C., Korf, H.W. J. Neurochem. (2003) [Pubmed]
  14. Rat and Syrian hamster: two models for the regulation of AANAT gene expression. Simonneaux, V., Sinitskaya, N., Salingre, A., Garidou, M.L., Pévet, P. Chronobiol. Int. (2006) [Pubmed]
  15. Regulation of arylalkylamine N-acetyltransferase (AANAT) in the retina. Tosini, G., Chaurasia, S.S., Michael Iuvone, P. Chronobiol. Int. (2006) [Pubmed]
  16. Protein kinase C regulates the activity and stability of serotonin N-acetyltransferase. Choi, B.H., Chae, H.D., Park, T.J., Oh, J., Lim, J., Kang, S.S., Ha, H., Kim, K.T. J. Neurochem. (2004) [Pubmed]
  17. In vivo observation of a non-noradrenergic regulation of arylalkylamine N-acetyltransferase gene expression in the rat pineal complex. Garidou, M.L., Bartol, I., Calgari, C., Pévet, P., Simonneaux, V. Neuroscience (2001) [Pubmed]
  18. Inhibition of p38 mitogen-activated protein kinase enhances adrenergic-stimulated arylalkylamine N-acetyltransferase activity in rat pinealocytes. Man, J.R., Rustaeus, S., Price, D.M., Chik, C.L., Ho, A.K. Endocrinology (2004) [Pubmed]
  19. Serine/threonine phosphatase inhibitors decrease adrenergic arylalkylamine n-acetyltransferase induction in the rat pineal gland. Spessert, R., Rapp, M., Vollrath, L. J. Neuroendocrinol. (2001) [Pubmed]
  20. Rhythmic control of AANAT translation by hnRNP Q in circadian melatonin production. Kim, T.D., Woo, K.C., Cho, S., Ha, D.C., Jang, S.K., Kim, K.T. Genes Dev. (2007) [Pubmed]
  21. Accumulation of rat pineal serotonin N-acetyltransferase mRNA induced by pituitary adenylate cyclase activating polypeptide and vasoactive intestinal peptide in vitro. Rekasi, Z., Czompoly, T. J. Mol. Endocrinol. (2002) [Pubmed]
  22. Hypothalamus-pituitary-thyroid axis interactions with pineal gland in the rat. Brammer, G.L., Morley, J.E., Geller, E., Yuwiler, A., Hershman, J.M. Am. J. Physiol. (1979) [Pubmed]
  23. Signal transmission from the suprachiasmatic nucleus to the pineal gland via the paraventricular nucleus: analysed from arg-vasopressin peptide, rPer2 mRNA and AVP mRNA changes and pineal AA-NAT mRNA after the melatonin injection during light and dark periods. Isobe, Y., Nishino, H. Brain Res. (2004) [Pubmed]
  24. Lack of effect of oxytocin on the numbers of "synaptic" ribbons, cyclic guanosine monophosphate and serotonin N-acetyltransferase activity in organ-cultured pineals of three strains of rats. Reuss, S., Mattern, E., Spessert, R., Riemann, R., Weber, A., Vollrath, L. Cell Tissue Res. (1993) [Pubmed]
  25. Twenty-four-hour pineal melatonin synthesis in the vasopressin-deficient Brattleboro rat. Schröder, H., Stehle, J., Henschel, M. Brain Res. (1988) [Pubmed]
  26. Opposite effects of proteasome inhibitors in the adrenergic induction of arylalkylamine N-acetyltransferase in rat pinealocytes. Ho, A.K., Terriff, D.L., Price, D.M., Chik, C.L. Chronobiol. Int. (2006) [Pubmed]
  27. Chronic fluoxetine administration increases the serotonin N-acetyltransferase messenger RNA content in rat hippocampus. Uz, T., Manev, H. Biol. Psychiatry (1999) [Pubmed]
  28. Multiple forms of arylalkylamine N-acetyltransferases in the rat pineal gland: purification of one molecular form. Namboodiri, M.A., Brownstein, M.J., Weller, J., Voisin, P., Klein, D.C. J. Pineal Res. (1987) [Pubmed]
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