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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Cell proliferation in rat kidney induced by 1,2-dibromoethane.

The effect of a single intragastric injection of 1,2-dibromoethane was investigated in kidneys of male Wistar rats. DNA synthesis as measured by the incorporation of tritiated thymidine was found to be approximately 5 times greater than that of controls 20-30 h after treatment. DNA synthesis was followed by a striking increase in the mitotic activity with a maximum at 30 h. The labeling and mitotic activities, after an initial increase, fell rapidly 48 h after treatment even though they were still higher than those of control animals. 1,2-Dibromoethane-induced cell proliferation is not a regenerative response because at the dose used in this study, no tubular necrosis was observed by histologic examination.[1]


  1. Cell proliferation in rat kidney induced by 1,2-dibromoethane. Ledda-Columbano, G.M., Columbano, A., Coni, P., Curto, M., Faa, G., Pani, P. Toxicol. Lett. (1987) [Pubmed]
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