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Budde-Steffen, C. et al.

An antineuronal autoantibody in paraneoplastic opsoclonus.

Sera from 7 patients with paraneoplastic opsoclonus were examined for antineuronal autoantibodies. An antibody against neuronal nuclei was found in serum from a patient with breast cancer, opsoclonus, and ataxia. This antibody recognized 53- to 61-kDa and 79- to 84-kDa antigens in immunoblots of neurons. Antineuronal antibodies were not found in other patients with paraneoplastic opsoclonus.[1]

References

An antineuronal autoantibody in paraneoplastic opsoclonus. Budde-Steffen, C., Anderson, N.E., Rosenblum, M.K., Graus, F., Ford, D., Synek, B.J., Wray, S.H., Posner, J.B. Ann. Neurol. (1988) [Pubmed]

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