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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Transnitrosating activity of N-nitroso-N-methyl-p-toluenesulfonamide in rats and human gastric juice.

N-nitroso-N-methyl-p-toluenesulfonamide (NMTS, diazald, CAS 80-11-5) is a widely used compound for laboratory production of diazomethane. The present results showed that the noncarcinogenic NMTS reacts as a transnitrosating agent with amino nitrogen of secondary amines and amide both in vitro (human gastric juice) and in vivo (rats) to yield N-nitroso compounds. Since all compounds formed (NMOR, NDMA, NPIP, NPZ, NMU) are known animal carcinogens, caution should be taken by users handling NMTS.[1]

References

  1. Transnitrosating activity of N-nitroso-N-methyl-p-toluenesulfonamide in rats and human gastric juice. Börzsönyi, M., Sajgó, K., Török, G., Pintér, A., Tamás, J., Kolar, G., Spiegelhalder, B. Neoplasma (1988) [Pubmed]
 
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