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Gene Review:

NPIPA1 - nuclear pore complex interacting protein...

Homo sapiens

Synonyms: NPIP, NPIPA, Nuclear pore complex-interacting protein, Nuclear pore complex-interacting protein family member A1, morpheus

Young-Sciame, R. et al., Perdu, J. et al., Dawson, B.A. et al., Nebelin, E. et al., Börzsönyi, M. et al., et al.

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Disease relevance of NPIP

In a comprehensive mutational screening, we have analysed the entire coding region of the pM5, MRP1, and NPIP genes in 7 patients affected with pseudoxanthoma elasticum, but failed to find evidence of disease-causing defects in any of these three genes [1].

High impact information on NPIP

N-Nitrosopiperidine (NPIP; 0.6 microgram/day) and N-nitrosopyrrolidine (NPYR; 0.4 microgram/day) were also present in one sample [2].
The goal of this study was to compare the reactions of alpha-acetoxy-N-nitrosopyrrolidine (alpha-acetoxyNPYR) and alpha-acetoxy-N-nitrosopiperidine (alpha-acetoxyNPIP) with deoxyguanosine (dG). alpha-AcetoxyNPYR and alpha-acetoxyNPIP are stable precursors to the alpha-hydroxynitrosamines which are formed metabolically from NPYR and NPIP [3].
Since all compounds formed (NMOR, NDMA, NPIP, NPZ, NMU) are known animal carcinogens, caution should be taken by users handling NMTS [4].
A quantitative method is described for the measurement of N-mononitrosopiperazine (NPIP) and N,N'-dinitrosopiperazine (DNPIP) in drug formulations containing piperazine, using a gas chromatograph interfaced to a thermal energy analyzer (GC/TEA) [5].
The formation of NPYR and NPIP from proline, pyrrolidine, putrescine, spermidine and cadaverine was studied in a model experiment, using minced bacon as the reaction medium [6].

References

Identification of novel polymorphisms in the pM5 and MRP1 (ABCC1) genes at locus 16p13.1 and exclusion of both genes as responsible for pseudoxanthoma elasticum. Perdu, J., Germain, D.P. Hum. Mutat. (2001) [Pubmed]
Nitrate, nitrite and volatile N-nitroso compounds in the urine of Schistosoma haematobium and Schistosoma mansoni infected patients. Mostafa, M.H., Helmi, S., Badawi, A.F., Tricker, A.R., Spiegelhalder, B., Preussmann, R. Carcinogenesis (1994) [Pubmed]
Reactions of alpha-acetoxy-N-nitrosopyrrolidine and alpha-acetoxy-N-nitrosopiperidine with deoxyguanosine: formation of N2-tetrahydrofuranyl and N2-tetrahydropyranyl adducts. Young-Sciame, R., Wang, M., Chung, F.L., Hecht, S.S. Chem. Res. Toxicol. (1995) [Pubmed]
Transnitrosating activity of N-nitroso-N-methyl-p-toluenesulfonamide in rats and human gastric juice. Börzsönyi, M., Sajgó, K., Török, G., Pintér, A., Tamás, J., Kolar, G., Spiegelhalder, B. Neoplasma (1988) [Pubmed]
Analysis of piperazine drug formulations for N-nitrosamines. Dawson, B.A., Lawrence, R.C. Journal - Association of Official Analytical Chemists. (1987) [Pubmed]
On the formation of N-nitrosopyrrolidine from potential precursors and nitrite. Nebelin, E., Pillai, S., Lund, E., Thomsen, J. IARC Sci. Publ. (1980) [Pubmed]

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