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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Dopaminergic supersensitivity after long-term bromopride treatment.

The effects of bromopride administration on open-field and apomorphine-induced stereotyped behavior of rats were studied. Bromopride induced a displacement to the right of the control dose-response curve constructed for apomorphine stereotypes. Withdrawal from long-term bromopride treatment induced not only a significant increase in ambulation and rearing frequencies for male rats observed in the open-field but also an increased sensitivity of both male and female animals to apomorphine. The results are interpreted as a consequence of the development of supersensitivity of central dopaminergic receptors, probably of the mesostriatal pathways.[1]

References

  1. Dopaminergic supersensitivity after long-term bromopride treatment. Felicio, L.F., Nasello, A.G., Palermo-Neto, J. Physiol. Behav. (1987) [Pubmed]
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