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Harris, S.S. et al.

In vivo and in vitro study of the effects of vitamin A deficiency on rat third molar development.

We have examined the effect of in vivo vitamin A status on subsequent rat third molar formation and mineralization in an in vitro organ culture system. Vitamin A deficiency imposed during an eight-day in vitro period caused effects very similar to those of vitamin A deficiency imposed on rats in vivo. Analysis of the data also demonstrates that retinoic acid is capable of reversing the interference in mineralization of third molars induced by vitamin A deficiency in the organ culture system.[1]

References

In vivo and in vitro study of the effects of vitamin A deficiency on rat third molar development. Harris, S.S., Navia, J.M. J. Dent. Res. (1986) [Pubmed]

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