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MeSH Review

Organ Culture Techniques

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Disease relevance of Organ Culture Techniques


Psychiatry related information on Organ Culture Techniques

  • Transforming growth factor beta 1 (TGF-beta 1) has been shown to play a prominent role in controlling proteoglycan synthesis and breakdown as measured following addition to organ cultures of calf articular cartilage (Morales, T. I., and Roberts, A. B., J. Biol. Chem., 263, 12,828-12,831, 1988) [6].

High impact information on Organ Culture Techniques


Chemical compound and disease context of Organ Culture Techniques


Biological context of Organ Culture Techniques


Anatomical context of Organ Culture Techniques


Associations of Organ Culture Techniques with chemical compounds

  • Biological activities of prostaglandin analogues and metabolites on bone in organ culture [27].
  • Carbon-13 nuclear magnetic resonance spectroscopy has been used in the study of glucose metabolism, specifically aldose reductase inhibition, in intact rabbit lenses maintained in organ culture [28].
  • Two divalent cation ionophores, A23187 and Ionomycin, which are selective for calcium, stimulated the resorption of fetal rat long bones in organ culture at 0.1 to 1 micromolar but not at higher concentrations [29].
  • Addition of choleragen to rat pineal organ cultures caused a long-lasting stimulation of adenylate cyclase activity, and this was followed by increases in seroton N-acetyltransferase and cyclic adenosine monophosphate phosphodiesterase activities [30].
  • However, if tolerogen were present for 3--5 d during organ culture there was near total elimination of potential DNP clones [31].

Gene context of Organ Culture Techniques

  • In fetal thymic organ cultures from Lef1-/- Tcf1-/- mice, alpha/beta T cell differentiation is completely arrested at the immature CD8+ single-positive (CD8+ ISP) stage and is markedly impaired at an earlier stage [32].
  • The Ad.RSV hIL-1ra-treated cartilage samples were resistant to IL1-induced proteoglycan degradation over 10 d of sustained organ culture [33].
  • Using short-term human skin organ culture, we found that autocrine EGF receptor activation could account for this observation [34].
  • We have investigated the mitogenic and morphogenic functions of Sonic hedgehog (Shh) on enteric NCCs in cell and organ culture [35].
  • Using thymic organ culture, this study demonstrates that both BMP4 and FGF7/FGF10 arrest early T-cell development at the CD4-CD8-CD44+CD25- (double-negative 1 [DN1]) population and at the CD4-CD8- double-negative (DN) to CD4+CD8+ double-positive (DP) transition in a stromal compartment-dependent manner [36].

Analytical, diagnostic and therapeutic context of Organ Culture Techniques


  1. Evidence for a differential avidity model of T cell selection in the thymus. Ashton-Rickardt, P.G., Bandeira, A., Delaney, J.R., Van Kaer, L., Pircher, H.P., Zinkernagel, R.M., Tonegawa, S. Cell (1994) [Pubmed]
  2. Bone resorption in organ culture: inhibition by the divalent cation ionophores A23187 and X-537A. Ivey, J.L., Wright, D.R., Tashjian, A.H. J. Clin. Invest. (1976) [Pubmed]
  3. Inhibition and reversal by beta-retinoic acid of hyperplasia induced in cultured mouse prostate tissue by 3-methylcholanthrene or N-methyl-N'-nitro-N-nitrosoguanidine. Chopra, D.P., Wilkoff, L.J. J. Natl. Cancer Inst. (1976) [Pubmed]
  4. Leukemia inhibitory factor inhibits HIV-1 replication and is upregulated in placentae from nontransmitting women. Patterson, B.K., Behbahani, H., Kabat, W.J., Sullivan, Y., O'Gorman, M.R., Landay, A., Flener, Z., Khan, N., Yogev, R., Andersson, J. J. Clin. Invest. (2001) [Pubmed]
  5. Plasminogen activators in human malignant melanoma. Markus, G., Kohga, S., Camiolo, S.M., Madeja, J.M., Ambrus, J.L., Karakousis, C. J. Natl. Cancer Inst. (1984) [Pubmed]
  6. Transforming growth factor-beta in calf articular cartilage organ cultures: synthesis and distribution. Morales, T.I., Joyce, M.E., Sobel, M.E., Danielpour, D., Roberts, A.B. Arch. Biochem. Biophys. (1991) [Pubmed]
  7. CD81 (TAPA-1): a molecule involved in signal transduction and cell adhesion in the immune system. Levy, S., Todd, S.C., Maecker, H.T. Annu. Rev. Immunol. (1998) [Pubmed]
  8. The interleukin-2 receptor gamma chain: its role in the multiple cytokine receptor complexes and T cell development in XSCID. Sugamura, K., Asao, H., Kondo, M., Tanaka, N., Ishii, N., Ohbo, K., Nakamura, M., Takeshita, T. Annu. Rev. Immunol. (1996) [Pubmed]
  9. The Wilms tumor suppressor WT1 encodes a transcriptional activator of amphiregulin. Lee, S.B., Huang, K., Palmer, R., Truong, V.B., Herzlinger, D., Kolquist, K.A., Wong, J., Paulding, C., Yoon, S.K., Gerald, W., Oliner, J.D., Haber, D.A. Cell (1999) [Pubmed]
  10. Direct induction by estradiol on vitellogenin synthesis in organ cultures of male Xenopus laevis liver. Green, C.D., Tata, J.R. Cell (1976) [Pubmed]
  11. Nonenzymatic hydroxylations of proline and lysine by reduced oxygen derivatives. Trelstad, R.L., Lawley, K.R., Holmes, L.B. Nature (1981) [Pubmed]
  12. Inosine: a protective agent in an organ culture model of myocardial ischemia. Goldhaber, S.Z., Pohost, G.M., Kloner, R.A., Andrews, E., Newell, J.B., Ingwall, J.S. Circ. Res. (1982) [Pubmed]
  13. Estradiol-dependent collagenolytic enzyme activity in long-term organ culture of human breast cancer. Heuson, J.C., Pasteels, J.L., Legros, N., Heuson-Stiennon, J., Leclercq, G. Cancer Res. (1975) [Pubmed]
  14. Histological evaluation of in vitro responses of endometrial adenocarcinoma to progestins and their relation to progesterone receptor levels. Holinka, C.F., Deligdisch, L., Gurpide, E. Cancer Res. (1984) [Pubmed]
  15. Preservation of steroid hormone receptors in organ cultures of human breast carcinomas. Mira-y-Lopez, R., Ossowski, L. Cancer Res. (1990) [Pubmed]
  16. Suramin suppresses hypercalcemia and osteoclastic bone resorption in nude mice bearing a human squamous cancer. Yoneda, T., Williams, P., Rhine, C., Boyce, B.F., Dunstan, C., Mundy, G.R. Cancer Res. (1995) [Pubmed]
  17. Rhodopsin-like photosensitivity of isolated chicken pineal gland. Deguchi, T. Nature (1981) [Pubmed]
  18. A targeted glucocorticoid receptor antisense transgene increases thymocyte apoptosis and alters thymocyte development. King, L.B., Vacchio, M.S., Dixon, K., Hunziker, R., Margulies, D.H., Ashwell, J.D. Immunity (1995) [Pubmed]
  19. Constitutive expression of PU.1 in fetal hematopoietic progenitors blocks T cell development at the pro-T cell stage. Anderson, M.K., Weiss, A.H., Hernandez-Hoyos, G., Dionne, C.J., Rothenberg, E.V. Immunity (2002) [Pubmed]
  20. Protein kinase B regulates T lymphocyte survival, nuclear factor kappaB activation, and Bcl-X(L) levels in vivo. Jones, R.G., Parsons, M., Bonnard, M., Chan, V.S., Yeh, W.C., Woodgett, J.R., Ohashi, P.S. J. Exp. Med. (2000) [Pubmed]
  21. Selective inhibitors of the osteoblast proteasome stimulate bone formation in vivo and in vitro. Garrett, I.R., Chen, D., Gutierrez, G., Zhao, M., Escobedo, A., Rossini, G., Harris, S.E., Gallwitz, W., Kim, K.B., Hu, S., Crews, C.M., Mundy, G.R. J. Clin. Invest. (2003) [Pubmed]
  22. Activity of vitamin A analogues in cell cultures of mouse epidermis and organ cultures of hamster trachea. Sporn, M.B., Clamon, G.H., Dunlop, N.M., Newton, D.L., Smith, J.M., Saffiotti, U. Nature (1975) [Pubmed]
  23. Biosynthesis of biopterin: adrenergic cyclic adenosine monophosphate-dependent inhibition in the pineal gland. Kapatos, G., Kaufman, S., Weller, J.L., Klein, D.C. Science (1981) [Pubmed]
  24. Cortisol stimulation of parathyroid hormone secretion by rat parathyroid glands in organ culture. Au, W.Y. Science (1976) [Pubmed]
  25. Positive selection of CD8+ T cells induced by major histocompatibility complex binding peptides in fetal thymic organ culture. Hogquist, K.A., Gavin, M.A., Bevan, M.J. J. Exp. Med. (1993) [Pubmed]
  26. Evidence that activated mucosal T cells play a role in the pathogenesis of enteropathy in human small intestine. MacDonald, T.T., Spencer, J. J. Exp. Med. (1988) [Pubmed]
  27. Biological activities of prostaglandin analogues and metabolites on bone in organ culture. Tashjian, A.H., Tice, J.E., Sides, K. Nature (1977) [Pubmed]
  28. Study of aldose reductase inhibition in intact lenses by 13C nuclear magnetic resonance spectroscopy. Williams, W.F., Odom, J.D. Science (1986) [Pubmed]
  29. Divalent cation ionophores stimulate resorption and inhibit DNA synthesis in cultured fetal rat bone. Lorenzo, J.A., Raisz, L.G. Science (1981) [Pubmed]
  30. Cholera toxin induces pineal enzymes in culture. Minneman, K.P., Iversen, L.L. Science (1976) [Pubmed]
  31. Ontogenic development of B-lymphocyte function and tolerance susceptibility in vivo and in an in vitro organ culture system. Teale, J.M., Mandel, T.E. J. Exp. Med. (1980) [Pubmed]
  32. Redundant regulation of T cell differentiation and TCRalpha gene expression by the transcription factors LEF-1 and TCF-1. Okamura, R.M., Sigvardsson, M., Galceran, J., Verbeek, S., Clevers, H., Grosschedl, R. Immunity (1998) [Pubmed]
  33. Transplantation of transduced chondrocytes protects articular cartilage from interleukin 1-induced extracellular matrix degradation. Baragi, V.M., Renkiewicz, R.R., Jordan, H., Bonadio, J., Hartman, J.W., Roessler, B.J. J. Clin. Invest. (1995) [Pubmed]
  34. Heparin-binding ligands mediate autocrine epidermal growth factor receptor activation In skin organ culture. Stoll, S., Garner, W., Elder, J. J. Clin. Invest. (1997) [Pubmed]
  35. Sonic hedgehog regulates the proliferation, differentiation, and migration of enteric neural crest cells in gut. Fu, M., Lui, V.C., Sham, M.H., Pachnis, V., Tam, P.K. J. Cell Biol. (2004) [Pubmed]
  36. BMP4 acts upstream of FGF in modulating thymic stroma and regulating thymopoiesis. Tsai, P.T., Lee, R.A., Wu, H. Blood (2003) [Pubmed]
  37. Leukemia inhibitory factor is expressed in cartilage and synovium and can contribute to the pathogenesis of arthritis. Lotz, M., Moats, T., Villiger, P.M. J. Clin. Invest. (1992) [Pubmed]
  38. Production of antiendomysial antibodies after in-vitro gliadin challenge of small intestine biopsy samples from patients with coeliac disease. Picarelli, A., Maiuri, L., Frate, A., Greco, M., Auricchio, S., Londei, M. Lancet (1996) [Pubmed]
  39. Cytoskeleton of intestinal goblet cells in rabbit and monkey. The theca. Specian, R.D., Neutra, M.R. Gastroenterology (1984) [Pubmed]
  40. Synthesis of acetylcholine receptor by denervated rat diaphragm muscle. Brockes, J.P., Hall, Z.W. Proc. Natl. Acad. Sci. U.S.A. (1975) [Pubmed]
  41. Effects of adrenocorticotropic hormone, human chorionic gonadotropin, and insulin on steroid production by human adrenocortical carcinoma cells in culture. Wen, X.L., Villee, D.B., Ellison, P., Todd, R., Loring, J. Cancer Res. (1985) [Pubmed]
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