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MeSH Review

Organ Culture Techniques

 
 
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Disease relevance of Organ Culture Techniques

 

Psychiatry related information on Organ Culture Techniques

  • Transforming growth factor beta 1 (TGF-beta 1) has been shown to play a prominent role in controlling proteoglycan synthesis and breakdown as measured following addition to organ cultures of calf articular cartilage (Morales, T. I., and Roberts, A. B., J. Biol. Chem., 263, 12,828-12,831, 1988) [6].
 

High impact information on Organ Culture Techniques

 

Chemical compound and disease context of Organ Culture Techniques

 

Biological context of Organ Culture Techniques

 

Anatomical context of Organ Culture Techniques

 

Associations of Organ Culture Techniques with chemical compounds

  • Biological activities of prostaglandin analogues and metabolites on bone in organ culture [27].
  • Carbon-13 nuclear magnetic resonance spectroscopy has been used in the study of glucose metabolism, specifically aldose reductase inhibition, in intact rabbit lenses maintained in organ culture [28].
  • Two divalent cation ionophores, A23187 and Ionomycin, which are selective for calcium, stimulated the resorption of fetal rat long bones in organ culture at 0.1 to 1 micromolar but not at higher concentrations [29].
  • Addition of choleragen to rat pineal organ cultures caused a long-lasting stimulation of adenylate cyclase activity, and this was followed by increases in seroton N-acetyltransferase and cyclic adenosine monophosphate phosphodiesterase activities [30].
  • However, if tolerogen were present for 3--5 d during organ culture there was near total elimination of potential DNP clones [31].
 

Gene context of Organ Culture Techniques

  • In fetal thymic organ cultures from Lef1-/- Tcf1-/- mice, alpha/beta T cell differentiation is completely arrested at the immature CD8+ single-positive (CD8+ ISP) stage and is markedly impaired at an earlier stage [32].
  • The Ad.RSV hIL-1ra-treated cartilage samples were resistant to IL1-induced proteoglycan degradation over 10 d of sustained organ culture [33].
  • Using short-term human skin organ culture, we found that autocrine EGF receptor activation could account for this observation [34].
  • We have investigated the mitogenic and morphogenic functions of Sonic hedgehog (Shh) on enteric NCCs in cell and organ culture [35].
  • Using thymic organ culture, this study demonstrates that both BMP4 and FGF7/FGF10 arrest early T-cell development at the CD4-CD8-CD44+CD25- (double-negative 1 [DN1]) population and at the CD4-CD8- double-negative (DN) to CD4+CD8+ double-positive (DP) transition in a stromal compartment-dependent manner [36].
 

Analytical, diagnostic and therapeutic context of Organ Culture Techniques

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  33. Transplantation of transduced chondrocytes protects articular cartilage from interleukin 1-induced extracellular matrix degradation. Baragi, V.M., Renkiewicz, R.R., Jordan, H., Bonadio, J., Hartman, J.W., Roessler, B.J. J. Clin. Invest. (1995) [Pubmed]
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