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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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DNA sequence for a low-level promoter of the lac repressor gene and an 'up' promoter mutation.

The promoter for a weakly expressed constitutive gene, the lactose repressor gene (lacI), has been sequenced, along with an 'up' promoter mutation Iq. The 10-fold enhancement in I expression found in Iq is the result of a single base change at position -35. To facilitate the sequencing, the lacI gene was cloned in a small plasmid.[1]

References

  1. DNA sequence for a low-level promoter of the lac repressor gene and an 'up' promoter mutation. Calos, M.P. Nature (1978) [Pubmed]
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