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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Molecular basis of base substitution hotspots in Escherichia coli.

In the lacI gene of Escherichia coli spontaneous base substituion hotspots occur at 5-methylcytosine residues. The hotspots disappear when the respective cytosines are not methylated. We suggest that the hotspots may result from the spontaneous deamination of 5-methylcytosine to thymine, which is not excised by the enzyme DNA-uracil glycosidase.[1]

References

  1. Molecular basis of base substitution hotspots in Escherichia coli. Coulondre, C., Miller, J.H., Farabaugh, P.J., Gilbert, W. Nature (1978) [Pubmed]
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