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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Norethindrone inhibition of testosterone secretion by an ovarian Sertoli-Leydig cell tumor.

A woman with severe hyperandrogenemia and virilization was found to have a fall in serum testosterone (T) concentration while taking an oral contraceptive containing norethindrone (500 vs. 164 ng/dL). Subsequent surgical exploration revealed an ovarian Sertoli-Leydig cell tumor. In vitro, the tumor secreted T (mean, 1.88 ng/mg X 4 h). hCG did not stimulate T secretion. In addition, norethindrone inhibited T secretion (0.33 ng/mg X 4 h). We conclude that norethindrone directly suppressed T production by the Sertoli-Leydig cell tumor.[1]

References

  1. Norethindrone inhibition of testosterone secretion by an ovarian Sertoli-Leydig cell tumor. Brumsted, J.R., Chapitis, J., Riddick, D., Gibson, M. J. Clin. Endocrinol. Metab. (1987) [Pubmed]
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