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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

alpha-(1H-imidazol-1-ylmethylene)ketones with antimycotic activity.

A series of title compounds were synthesized starting from heterocyclic alpha-hydroxymethyleneketones and 1,1'-carbonyldiimidazole and tested against gram-positive and gram-negative bacteria, as well as fungi. 7,8-Dihydro-6-(1H-imidazol-1-ylmethylene)-2-phenylquinazolin -5(6H)-one showed a remarkable activity against Candida krusei.[1]


  1. alpha-(1H-imidazol-1-ylmethylene)ketones with antimycotic activity. Mosti, L., Schenone, P., Menozzi, G., Pesce Schito, A., Debbia, E. Il Farmaco; edizione scientifica. (1987) [Pubmed]
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