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Chemical Compound Review

PubChem9667     diimidazol-1-ylmethanone

Synonyms: SureCN1325, CCRIS 2606, AG-K-79639, ACMC-209l3v, ANW-31625, ...
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Disease relevance of Carbonyldiimidazole


High impact information on Carbonyldiimidazole


Biological context of Carbonyldiimidazole

  • Substituted 3-amino-oxazolidin-2,4-diones have been prepared by reacting cyanohydrins or alpha-hydroxyesters subsequently with 1,1'-carbonyldiimidazole and 1,1-disubstituted hydrazines followed by acidic hydrolysis in case of the intermediate 3-amino-4-imino-oxazolidin-2-ones [7].
  • Although both antibody affinity matrices exhibited the same antigen binding capacities, the matrix prepared using carbonyldiimidazole-activated agarose bound the MNDA with a high level of specificity while the matrix prepared from CNBr-activated agarose bound numerous other nuclear proteins [8].

Anatomical context of Carbonyldiimidazole


Associations of Carbonyldiimidazole with other chemical compounds


Gene context of Carbonyldiimidazole


Analytical, diagnostic and therapeutic context of Carbonyldiimidazole

  • Insulin receptors purified from human placenta by sequential affinity chromatography on wheat germ lectin-agarose and insulin coupled to 1,1'-carbonyldiimidazole-activated agarose (CDI-agarose) retained full binding activity but bound a greater than predicted amount of 125I-labeled insulin-like growth factor I (IGF-I) [23].
  • In one method, the epoxy groups of this copolymer were used directly for the immobilization of HSA through its amine residues (i.e., the epoxy method); in other approaches, these epoxy groups were converted to diols for later use in the carbonyldiimidazole, disuccinimidyl carbonate, and Schiff base methods [24].
  • Covalent linkage of antisera to microparticulate cellulose using 1,1'-carbonyldiimidazole: a rapid, practical method with potential use in solid-phase immunoassay [25].


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  15. Potent inhibitors of human inosine monophosphate dehydrogenase type II. Fluorine-substituted analogues of thiazole-4-carboxamide adenine dinucleotide. Zatorski, A., Goldstein, B.M., Colby, T.D., Jones, J.P., Pankiewicz, K.W. J. Med. Chem. (1995) [Pubmed]
  16. Analysis of affinity supports by 13C CP/MAS NMR spectroscopy: application to carbonyldiimidazole- and novel tresyl chloride-synthesized agarose and silica gels. Zumbrink, T., Demiroglou, A., Jennissen, H.P. J. Mol. Recognit. (1995) [Pubmed]
  17. Parallel synthesis of tri- and tetrasubstituted ureas from carbamoyl imidazolium salts. Batey, R.A., Shen, M., Santhakumar, V., Yoshina-Ishii, C. Comb. Chem. High Throughput Screen. (2002) [Pubmed]
  18. A new procedure for the synthesis of polyethylene glycol-protein adducts; effects on function, receptor recognition, and clearance of superoxide dismutase, lactoferrin, and alpha 2-macroglobulin. Beauchamp, C.O., Gonias, S.L., Menapace, D.P., Pizzo, S.V. Anal. Biochem. (1983) [Pubmed]
  19. Application of 1,1'-carbonyldiimidazole-activated matrices for the purification of proteins. III. The use of 1,1'-carbonyldiimidazole-activated agaroses in the biospecific affinity chromatographic isolation of serum antibodies. Hearn, M.T., Harris, E.L., Bethell, G.S., Hancock, W.S., Ayers, J.A. J. Chromatogr. (1981) [Pubmed]
  20. A laminin and nerve growth factor-laden three-dimensional scaffold for enhanced neurite extension. Yu, X., Dillon, G.P., Bellamkonda, R.B. Tissue engineering. (1999) [Pubmed]
  21. A reliable method for generating antibodies against pancreozymin, secretin and gastrin. Schlegel, W., Raptis, S. Clin. Chim. Acta (1976) [Pubmed]
  22. Synthesis and characterization of steroid-linked N-(2-chloroethyl)nitrosoureas. Eisenbrand, G., Fischer, J., Mühlbauer, K., Schied, G., Schreiber, J., Tang, W., Zelezny, O. Arch. Pharm. (Weinheim) (1989) [Pubmed]
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  25. Covalent linkage of antisera to microparticulate cellulose using 1,1'-carbonyldiimidazole: a rapid, practical method with potential use in solid-phase immunoassay. Chapman, R.S., Ratcliffe, J.G. Clin. Chim. Acta (1982) [Pubmed]
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