Genotoxic potential of an organophosphate insecticide, phosphamidon (dimecron): an in vivo study in mice.
The genotoxic effect of phosphamidon in mice in an in vivo test system was investigated by 3 different assays: chromosomal aberration, micronucleus and sperm-shape abnormality. The chemical was administered to groups of mice via 3 routes (i.p., p.o. and s.c.), acutely in 3 dose regimens (5, 4 and 3 mg/kg) and subacutely or chronically (5 X 1 mg/kg). The animals were sacrificed at different times: after 6, 24, 48 and 120 h for chromosomal aberration, 30 h for micronucleus and 35 days for sperm-shape abnormality. Significant effects were observed in all assays. Chronic exposure to fractionated doses induced less effect than the equivalent acute dose. The results were dose- as well as time-responsive and indicated the genetic peril of phosphamidon in the present, in vivo system.[1]References
- Genotoxic potential of an organophosphate insecticide, phosphamidon (dimecron): an in vivo study in mice. Behera, B.C., Bhunya, S.P. Toxicol. Lett. (1987) [Pubmed]
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