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Chemical Compound Review

Dimecron     (Z)-2-chloro-3- dimethoxyphosphoryloxy-N,N...

Synonyms: Apamidon, Famfos, Fosfamidon, Merkon, Dixon, ...
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Disease relevance of PHOSPHAMIDON


Psychiatry related information on PHOSPHAMIDON

  • Daily decrease was observed in ambulation, rearing and preening responses, with maximum decrement on the seventh day of Dimecron intoxication [6].

High impact information on PHOSPHAMIDON

  • Both PHO and DED proved able to induce a dose-dependent increase of micronucleated polychromatic erythrocytes (PCE) [7].
  • Two pesticides, organophosphate phosphamidon (PHO) and organochlorine dieldrin (DED) were assayed by the mouse bone marrow micronucleus test, to ascertain whether they showed genotoxic activity in vivo [7].
  • Vitamin C, when administered concurrently with a pesticide (endosulfan, phosphamidon or mancozeb), could significantly decrease the frequency of pesticide-induced clastogenic and mitosis-disruptive changes in the bone marrow cells of young Swiss albino mice [8].
  • Phosphamidon caused a positive inotropic effect, as indicated by increased maximum time derivative of left ventricular pressure and increased cardiac output [9].
  • Phosphamidon had in this preparation a biphasic effect on heart rate: at 10(-6) M concentration, heart rate increased, but at higher concentrations (10(-4)-10(-3) M) heart rate decreased significantly [9].

Chemical compound and disease context of PHOSPHAMIDON


Biological context of PHOSPHAMIDON


Anatomical context of PHOSPHAMIDON


Associations of PHOSPHAMIDON with other chemical compounds


Gene context of PHOSPHAMIDON


Analytical, diagnostic and therapeutic context of PHOSPHAMIDON

  • Stroke work and total pressure-volume area increased in a dose-dependent manner following perfusion with phosphamidon [9].
  • Phosphamidon, one of the organophosphorus compounds studied, showed complete degradation of the DNA after treatment [27].
  • Oral administration of phosphamidon in doses of 0.25 and 0.5 mg/kg per day for 120 days caused significant inactivation of carboxylesterase activity (16-32%) without eliciting any intoxicating signs apart from mild intermittent diarrhoea in the animals receiving the higher dose [28].
  • Phosphamidon was detected by thin-layer chromatography (TLC) from various CNS regions of the rats intoxicated with three doses (1.0, 1.5 and 2.0 mg/kg body-weight) intraperitoneally daily for seven days [29].


  1. The comparative cytogenetic effects of aldrin and phosphamidon. Georgian, L. Mutat. Res. (1975) [Pubmed]
  2. Modulation of carbohydrate metabolism in the selected tissues of marine prawn, Penaeus indicus (H. Milne Edwards), under phosphamidon-induced stress. Reddy, M.S., Rao, K.V. Ecotoxicol. Environ. Saf. (1988) [Pubmed]
  3. Genotoxic potential of an organophosphate insecticide, phosphamidon (dimecron): an in vivo study in mice. Behera, B.C., Bhunya, S.P. Toxicol. Lett. (1987) [Pubmed]
  4. Disseminated Visceral Coccidiosis in a Wild White-naped Crane (Grus vipio). Kwon, Y.K., Jeon, W.J., Kang, M.I., Kim, J.H., Olsen, G.H. J. Wildl. Dis. (2006) [Pubmed]
  5. Effect of phosphamidon and obidoxime on the QT-RR relationship of isolated rat heart. Ben-Haim, S.A., Ben-Ami, H., Hayam, G., Taitelman, U., Edoute, Y. Pharmacol. Toxicol. (1992) [Pubmed]
  6. Regional alterations in the monoamine levels, monoamine oxidase activity & neurobehavioural effects in rats treated with Dimecron (phosphamidon). Naqvi, S.M., Hasan, M. Indian J. Med. Res. (1991) [Pubmed]
  7. Induction of micronuclei in bone marrow by two pesticides and their differentiation with CREST staining: an in vivo study in mice. Cicchetti, R., Bari, M., Argentin, G. Mutat. Res. (1999) [Pubmed]
  8. Antimutagenic efficacy of higher doses of vitamin C. Khan, P.K., Sinha, S.P. Mutat. Res. (1993) [Pubmed]
  9. Direct effects of phosphamidon on isolated working rat heart electrical and mechanical function. Ben-Ami, H., Ben-Haim, S.A., Edoute, Y., Hayam, G., Taitelman, U. Toxicol. Appl. Pharmacol. (1991) [Pubmed]
  10. Protective effect induced by atropine, carbamates, and 2-pyridine aldoxime methoiodide Artemia salina larvae exposed to fonofos and phosphamidon. Victoria Barahona, M., S??nchez-Fort??n, S. Ecotoxicol. Environ. Saf. (2007) [Pubmed]
  11. Inhibition and recovery of selected target enzyme activities in tissues of penaeid prawn, Metapenaeus monoceros (Fabricius), exposed to different insecticides. Rao, K.V., Ghouselazam, S., Surendranath, P. Indian J. Exp. Biol. (1991) [Pubmed]
  12. Impact of phosphamidon on the carbohydrate metabolism of a freshwater prawn, Macrobrachium lamarrei. Omkar, n.u.l.l., Upadhyay, V.B., Shukla, G.S. Environmental research. (1986) [Pubmed]
  13. Studies on the effect of dimecron on the digestive system of a fresh water fish, Channa punctatus. Sastry, K.V., Malik, P.V. Arch. Environ. Contam. Toxicol. (1979) [Pubmed]
  14. Evaluation of the teratogenic potential of phosphamidon in mice by gavage. Bhatnagar, P., Soni, I. Toxicol. Lett. (1988) [Pubmed]
  15. Mutagenicity of dimecron studied in 3 mosaic assays and the sex-linked recessive lethal test in Drosophila melanogaster. Tripathy, N.K., Majhi, B., Dey, L., Patnaik, K., Das, C.C. Mutat. Res. (1987) [Pubmed]
  16. Ameliorating effect of vitamin C on murine sperm toxicity induced by three pesticides (endosulfan, phosphamidon and mancozeb). Khan, P.K., Sinha, S.P. Mutagenesis (1996) [Pubmed]
  17. Effects of dimecron on developing chick embryo: malformations and other histopathological changes. Sahu, C.R., Ghatak, S. Anatomia, histologia, embryologia. (2002) [Pubmed]
  18. Apoptosis in male germinal line cells of rat in vivo: caused by phosphamidon. Akbarsha, M.A., Sivasamy, P. Cytobios (1997) [Pubmed]
  19. Neurochemical effects of phosphamidon on lipid fractions & lipid peroxidation in the rat central nervous system. Naqvi, S.M., Hasan, M., Haider, S.S. Indian J. Med. Res. (1988) [Pubmed]
  20. Detection and determination of organophosphorus insecticides in tissues by thin-layer chromatography. Tewari, S.N., Harpalani, S.P. J. Chromatogr. (1977) [Pubmed]
  21. In vivo recovery of acetylcholinesterase activity from phosphamidon and methylparathion induced inhibition in the nervous tissue of penaeid prawn (Metapenaeus monoceros). Reddy, M.S., Rao, K.V. Bulletin of environmental contamination and toxicology. (1988) [Pubmed]
  22. Sensitivity of selected zooplankton exposed to phosphamidon, fenitrothion, and fenthion. Kaur, K., Ansal, M.D. Bulletin of environmental contamination and toxicology. (1996) [Pubmed]
  23. Serotonin and benzylamine oxidation by type A and type B MAO of rat brain in presence of organophosphate pesticides. Nag, M., Nandy, N. Indian J. Exp. Biol. (2001) [Pubmed]
  24. The role of oxidative stress in the in vitro induction of micronuclei by pesticides in mouse lung fibroblasts. Cicchetti, R., Argentin, G. Mutagenesis (2003) [Pubmed]
  25. Comparative toxic potential of market formulation of two organophosphate pesticides in transgenic Drosophila melanogaster (hsp70-lacZ). Gupta, S.C., Siddique, H.R., Saxena, D.K., Chowdhuri, D.K. Cell Biol. Toxicol. (2005) [Pubmed]
  26. Interaction of phosphamidon with neuropathy target esterase and acetylcholinesterase of hen brain. Jokanović, M., Maksimović, M., Stepanović, R.M. Arch. Toxicol. (1995) [Pubmed]
  27. Simple radioactive assay for the estimation of DNA breaks. Sreekumaran Nair, R., Paulmurugan, R., Singh, A.J. Journal of applied toxicology : JAT. (2002) [Pubmed]
  28. The effect of long-term exposure to phosphamidon on the ruminal microorganisms and circulating carboxylesterase of Bubalus bubalis. Awal, M.A., Malik, J.K. Vet. Res. Commun. (1992) [Pubmed]
  29. Dose-related accumulation of organophosphate phosphamidon in discrete regions of the CNS: correlation with its neurotoxicity. Naqvi, S.M., Hasan, M. Pharmacol. Toxicol. (1990) [Pubmed]
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