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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

2-Pyrrolidinone in human cerebrospinal fluid: a major constituent of total gamma-aminobutyric acid.

2-Pyrrolidinone, the lactam of gamma-aminobutyric acid (GABA), is identified as the major constituent of total GABA in human CSF. Structural elucidation was done by mass spectrometry. In lumbar CSF of four patients, 2-pyrrolidinone represented about 54% of GABA found after acid hydrolysis, thus accounting for essentially all of the hitherto unknown GABA fraction in CSF.[1]

References

  1. 2-Pyrrolidinone in human cerebrospinal fluid: a major constituent of total gamma-aminobutyric acid. Haegele, K.D., Schwartz, J.J., Schoun, J., Schmitt, A.H., Schechter, P.J. J. Neurochem. (1987) [Pubmed]
 
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