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Bone, M. et al.

Penetration of ciclacillin into bronchial secretions.

The penetration of ciclacillin into bronchial secretions was investigated in 105 patients undergoing bronchoscopy after a single oral dose of 500 mg ciclacillin. Comparison was made with 26 patients who received 500 mg ampicillin by mouth. Over a 6 to 8 hour period, ciclacillin achieved significantly higher levels in bronchial secretions but no statistically significant difference between serum ampicillin and ciclacillin levels was detected.[1]

References

Penetration of ciclacillin into bronchial secretions. Bone, M., Symonds, J., Dougan, P. Chemioterapia : international journal of the Mediterranean Society of Chemotherapy. (1986) [Pubmed]

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