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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Penetration of ciclacillin into bronchial secretions.

The penetration of ciclacillin into bronchial secretions was investigated in 105 patients undergoing bronchoscopy after a single oral dose of 500 mg ciclacillin. Comparison was made with 26 patients who received 500 mg ampicillin by mouth. Over a 6 to 8 hour period, ciclacillin achieved significantly higher levels in bronchial secretions but no statistically significant difference between serum ampicillin and ciclacillin levels was detected.[1]


  1. Penetration of ciclacillin into bronchial secretions. Bone, M., Symonds, J., Dougan, P. Chemioterapia : international journal of the Mediterranean Society of Chemotherapy. (1986) [Pubmed]
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