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Chemical Compound Review

Omnipen     (2R,5R,6S)-6-[[(2R)-2-amino- 2-phenyl...

Synonyms: Amblosin, Pentrexyl, Amcill, Polycillin, Ukapen, ...
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Disease relevance of ampicillin


Psychiatry related information on ampicillin


High impact information on ampicillin

  • The strain of Salmonella enterica serotype typhimurium known as definitive phage type 104 (DT104) is usually resistant to five drugs: ampicillin, chloramphenicol, streptomycin, sulfonamides, and tetracycline [10].
  • The side effects of ampicillin were limited to a single episode of urticaria in a mother who had no history of penicillin allergy [11].
  • Different CYC1 alleles can be conveniently recovered by digestion of total DNA from transformed strains with BgI II, a restriction endonuclease that does not cut the vector or the CYC1 gene, followed by transformation of Escherichia coli, selecting the ampicillin resistance gene carried on the original vector [12].
  • Ampicillin resistance is strictly related to ampC gene copy number thus we have been able to isolate ampicillin-resistant mutants carrying multiple ampC repeats [13].
  • Growth of strain 195 was resistant to ampicillin and vancomycin; its cell wall did not react with a peptidoglycan-specific lectin and its ultrastructure resembled S-layers of Archaea. Analysis of the 16S ribosomal DNA sequence of strain 195 indicated that it is a eubacterium without close affiliation to any known groups [14].

Chemical compound and disease context of ampicillin


Biological context of ampicillin

  • We have inserted sheared embryonic D. melanogaster DNA by the poly(dA-dt) connector method (Lobban and Kaiser, 1973) into the R1 restriction site of the ampicillin-resistant plasmid pSF2124 (So, Gill and Falkow, 1975) [20].
  • These findings are contrary to most recently reported experience, which has indicated a rapidly increasing incidence of antibiotic resistance, especially to ampicillin [21].
  • In areas where GBS disease is prevalent, we recommend screening pregnant women (34 to 36 weeks' gestation) and treating those colonized with GBS (with no history of penicillin hypersensitivity) with intravenous ampicillin during labor [22].
  • 447 were randomly allocated ampicillin (25-30 mg/kg body weight three times daily for 5 days) plus supportive care (continued breastfeeding, clearing of the nose, and paracetamol to control fever); 442 were allocated supportive care only [23].
  • The cosmid can be rescued from the transfected cells by cloning it directly into ampicillin-sensitive Escherichia coli [24].

Anatomical context of ampicillin


Associations of ampicillin with other chemical compounds


Gene context of ampicillin


Analytical, diagnostic and therapeutic context of ampicillin

  • For patients receiving the procaine penicillin-probenecid and ampicillin-probenecid regimens, minimum inhibitory concentrations to the treatment drugs were significantly higher in patients not cured than in those cured (P less than 0.01 fr penicillin and P less than 0.05 for ampicillin) [39].
  • At the 2-week follow-up, the percentages cured were 62% (277) in the ampicillin group and 58% (256) in the control group; 14% of both groups had progressed to moderate ARI; and 24% (107) and 28% (123), respectively, still had mild ARI [23].
  • Ampicillin treatment failure of apparently beta-lactamase-negative Haemophilus influenzae type b meningitis due to novel beta-lactamase [19].
  • Serotyping showed that most recurrences were reinfections with ampicillin-resistant strains [40].
  • Restriction enzyme analysis and heteroduplex studies of the 8.3 x 10(6)-dalton plasmids pCH1-pCH5, present in the ampicillin-resistant A. nidulans R-2 colonies obtained after transformation with pRI46, demonstrated that these plasmids consist of the complete sequence of Tn901 inserted at different places into plasmid pUH24 [41].


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