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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

A randomized double-blind trial of two low dose combined oral contraceptives.

Fifty-five women using Loestrin-20 (20 microgram ethinyl oestradiol and 1 mg norethisterone acetate) as an oral contraceptive have been compared with a like number using Microgynon-30 (30 microgram ethinyl oestradiol and 150 microgram levonorgestrel) in a randomized, double-blind trial. Despite the small sample size, the main finding in the trial is clear-cut; Loestrin-20 provides poor cycle control and is thus less acceptable as an oral contraceptive than Microgynon-30. Although there is also a suggestion that Loestrin-20 may be less effective than Microgynon-30, the difference in the accidental pregnancy rates is not statistically significant.[1]


  1. A randomized double-blind trial of two low dose combined oral contraceptives. Bounds, W., Vessey, M., Wiggins, P. British journal of obstetrics and gynaecology. (1979) [Pubmed]
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