The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Alpha 2-antiplasmin: functional characterization and metabolism in a heterozygote deficient patient.

An 81-year-old male with a mild life-long bleeding history and an alpha 2-antiplasmin (alpha 2-AP) plasma level of 55% biological activity and 41% antigen activity (normal range 80-140%) was studied. The ratio of plasminogen binding (PB):non-plasminogen binding ( NPB) alpha 2-AP assayed by modified crossed immunoelectrophoresis (CIE) was 7.3/2.7 (controls 6.3 +/- 0.49 SD/3.7 +/- 0.49 SD). The patient's alpha 2-AP showed decreased affinity for fibrin, i.e. 8.3% versus 32.4% of normal control alpha 2-AP associated with fibrin during clotting of plasma. A metabolic study performed with human purified 125I-alpha 2-AP (PB/ NPB 7.7/2.3) showed a plasma radioactivity disappearance half-life of 72.9 h (n 60.1 +/- 5.3 h) with a normal fractional catabolic rate and a reduced absolute catabolic (synthetic) rate of 0.70 mg/kg/day (n 2.10 +/- 0.60 mg/kg/day). The exchange between the central and third compartment was increased. The increased alpha 2-AP PB form and the increased plasma radioactivity disappearance half-life are suggestive of a slower conversion of the PB form into the NPB form and/or slower degradation of the PB form. The bleeding tendency in this patient could be explained by decreased synthesis of alpha 2-AP and decreased binding to fibrin.[1]

References

  1. Alpha 2-antiplasmin: functional characterization and metabolism in a heterozygote deficient patient. Knot, E.A., ten Cate, J.W., Lamping, R.J., Gie, L.K. Thromb. Haemost. (1986) [Pubmed]
 
WikiGenes - Universities