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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

A simple method for detection of heterozygous carriers of the gene for classic phenylketonuria.

Plasma phenylalanine (Phe) and tyrosine (Tyr) concentrations were measured by high-performance liquid chromatography in arteriolar blood obtained by finger prick from 78 normal volunteers and 36 heterozygote carriers of phenylketonuria (PKU). Subjects were tested at midday, 3 to 4 hours after their breakfast. Values for the micromolar ratio of Phe/Tyr and Phe2/Tyr for control subjects fell below 1.2 and 80, respectively; values for all carriers of PKU were higher for one or both ratios. This method should be applicable to widespread screening of the general population for carriers of the gene for PKU.[1]

References

  1. A simple method for detection of heterozygous carriers of the gene for classic phenylketonuria. Hilton, M.A., Sharpe, J.N., Hicks, L.G., Andrews, B.F. J. Pediatr. (1986) [Pubmed]
 
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