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Ichihara, S. et al.

Involvement of leukocytes in the oxygenation and chlorination reaction of phenylbutazone.

A center carbon atom of 1,3-diketone moiety of phenylbutazone was oxidized to give three metabolites--4-hydroxyphenylbutazone (metabolite I), 4-hydroperoxyphenylbutazone (metabolite II) and 4-chlorophenylbutazone (metabolite III)--by the action of enzymes present in leukocyte extract obtained from peritoneal exudate of rats. Both metabolites II and III were produced by peroxidases, while metabolite I was produced by enzymes other than the peroxidases.[1]

References

Involvement of leukocytes in the oxygenation and chlorination reaction of phenylbutazone. Ichihara, S., Tomisawa, H., Fukazawa, H., Tateishi, M., Joly, R., Heintz, R. Biochem. Pharmacol. (1986) [Pubmed]

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