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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Valine metabolism. Gluconeogenesis from 3-hydroxyisobutyrate.

During valine catabolism in muscle both 2-oxoisovalerate and 3-hydroxyisobutyrate can be released into the circulation. 3-Hydroxyisobutyrate is a good gluconeogenic substrate in isolated cortical tubules and hepatocytes. The maximal rate of gluconeogenesis from 3-hydroxyisobutyrate was greater than from 2-oxoisovalerate. We propose that 3-hydroxyisobutyrate is an inter-organ metabolite by which the gluconeogenic potential of valine, whose catabolism has been initiated in muscle, may be conserved.[1]

References

  1. Valine metabolism. Gluconeogenesis from 3-hydroxyisobutyrate. Letto, J., Brosnan, M.E., Brosnan, J.T. Biochem. J. (1986) [Pubmed]
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