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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Gamma-vinyl-GABA treatment of tardive dyskinesia and other movement disorders.

We conducted a single-blind trial of gamma-vinyl-GABA (GVG) in nine patients: seven with tardive dyskinesia, one with Meige syndrome, and one with Tourette syndrome. Five tardive dyskinesia patients completed the entire 11-week study and, as a group, demonstrated significant decreases in dyskinesia scores. Four of these five tardive dyskinesia patients showed clinically evident improvement, with approximately 30% reduction in dyskinetic symptoms. Other patients had no clinical benefit from GVG. Three patients had transient exacerbation of psychiatric symptoms after sudden withdrawal of GVG, and one patient experienced dose-related confusional episodes. Our results suggest that GABAergic drugs may have a role in treating patients with tardive dyskinesia.[1]


  1. Gamma-vinyl-GABA treatment of tardive dyskinesia and other movement disorders. Stahl, S.M., Thornton, J.E., Simpson, M.L., Berger, P.A., Napoliello, M.J. Biol. Psychiatry (1985) [Pubmed]
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