Disease relevance of Meige Syndrome

• A critical historical evaluation of the cranial dystonias supports the separation of the dystonia of the motor trigeminal nerve producing a widely opened mouth (Brueghel syndrome) from the more common facial dystonias with blepharospasm (Meige syndrome) [1].
• Cranial dystonia (Meige syndrome) in postencephalitic parkinsonism [2].
• One patient presented with a writer's cramp, one with axial dystonia, and one with Meige syndrome [3].
• A patient with Meige syndrome associated with spasmodic torticollis was treated with benztropine mesylate (Cogentin) at doses of 12-16 mg daily [4].

Psychiatry related information on Meige Syndrome

• To our knowledge, this is the first report demonstrating that Meige syndrome with apraxia of lid opening is induced by sulpiride, and that the condition persists [5].

High impact information on Meige Syndrome

• Sodium valproate appears to be ineffective in Meige syndrome [6].
• Lidocaine tape (Penles) reduces the pain of botulinum toxin injection for Meige syndrome [7].
• Blink reflex recovery cycle, before and after acute administration of orphenadrine chlorhydrate, was tested in Meige syndrome [8].
• Meige syndrome: treatment with trihexyphenidyl [9].
• Effect of clonazepam treatment on antipsychotic drug-induced Meige syndrome and changes in plasma levels of GABA, HVA, and MHPG during treatment [10].

Chemical compound and disease context of Meige Syndrome

• Finally, the unique combination of DA excess with ACh excess may characterize idiopathic orofacial dyskinesia (also known as Meige dystonia, Brueghel syndrome, and blepharospasm-oromandibular dystonia) [11].
• METHODS: Ten patients with benign essential blepharospasm and one patient with Meige syndrome were examined using positron emission tomography with deoxyglucose labeled with fluorine 18 [12].

Gene context of Meige Syndrome

• Meige syndrome (blepharospasm-oromandibular dystonia) after long-term neuroleptic therapy [13].

References